C₄₅H₅₉N₇O₁₀

Base Information

Chemical Name:C₄₅H₅₉N₇O₁₀
CAS No.:1272655-00-1
Molecular Formula:C₄₅H₅₉N₇O₁₀
Molecular Weight:858.004
Hs Code.:

C<sub>45</sub>H<sub>59</sub>N<sub>7</sub>O<sub>10</sub>

Synonyms:C₄₅H₅₉N₇O₁₀

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Chemical Property of C₄₅H₅₉N₇O₁₀

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Technology Process of C₄₅H₅₉N₇O₁₀

There total 22 articles about C₄₅H₅₉N₇O₁₀ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1272654-75-7
(3S,7S,9S)-7,9-dimethyl-2-{N-[(methyloxy)carbonyl]-L-valyl}-6,10-dioxa-2-azaspiro[4.5]decane-3-carboxylic acid

: methyl{(1S)-1-[((2S)-2-{4-[4'-(aminoacetyl)-4-biphenylyl]-1H-imidazol-2-yl}-1-pyrrolidinyl)carbonyl]-2-methylpropyl}carbamate dihydrochloride

: 1272655-00-1
C₄₅H₅₉N₇O₁₀

Guidance literature:: (3S,7S,9S)-7,9-dimethyl-2-{N-[(methyloxy)carbonyl]-L-valyl}-6,10-dioxa-2-azaspiro[4.5]decane-3-carboxylic acid; With triethylamine; HATU; In N,N-dimethyl-formamide; for 0.05h;

methyl{(1S)-1-[((2S)-2-{4-[4'-(aminoacetyl)-4-biphenylyl]-1H-imidazol-2-yl}-1-pyrrolidinyl)carbonyl]-2-methylpropyl}carbamate dihydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield: 61.0%

: 1272654-75-7
(3S,7S,9S)-7,9-dimethyl-2-{N-[(methyloxy)carbonyl]-L-valyl}-6,10-dioxa-2-azaspiro[4.5]decane-3-carboxylic acid

: methyl {(1S)-1-[((2S)-2-{4-4'-(aminoacetyl)-[4-biphenylyl]-1H-imidazol-2-yl}-1-pyrrolidinyl)carbonyl]-2-methylpropyl}carbamate dihydrochloride

: 1272655-00-1
C₄₅H₅₉N₇O₁₀

Guidance literature:: (3S,7S,9S)-7,9-dimethyl-2-{N-[(methyloxy)carbonyl]-L-valyl}-6,10-dioxa-2-azaspiro[4.5]decane-3-carboxylic acid; With triethylamine; HATU; In N,N-dimethyl-formamide; for 0.05h; Inert atmosphere;

methyl {(1S)-1-[((2S)-2-{4-4'-(aminoacetyl)-[4-biphenylyl]-1H-imidazol-2-yl}-1-pyrrolidinyl)carbonyl]-2-methylpropyl}carbamate dihydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 1272655-00-1
C₄₅H₅₉N₇O₁₀

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; HATU / dichloromethane / 0.17 h

1.2: 4 h / 20 °C

2.1: Dess-Martin periodane / dichloromethane / 4 h / 20 °C

3.1: toluene-4-sulfonic acid / toluene / Reflux; Dean stark trap

4.1: water; lithium hydroxide / tetrahydrofuran; tert-butyl alcohol / 2 h / 20 °C

4.2: pH 3

5.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.05 h

5.2: 2 h / 20 °C

With water; Dess-Martin periodane; triethylamine; HATU; lithium hydroxide; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;