1,2-bis<4-(difluoromethyl)phenyl>-1,1,2,2-tetrafluoroethane

Base Information

• Chemical Name: 1,2-bis<4-(difluoromethyl)phenyl>-1,1,2,2-tetrafluoroethane
• CAS No.: 13348-33-9
• Molecular Formula: C₁₆H₁₀F₈
• Molecular Weight: 354.243
• Mol file: 13348-33-9.mol

Synonyms:1,2-bis<4-(difluoromethyl)phenyl>-1,1,2,2-tetrafluoroethane

Chemical Property of 1,2-bis<4-(difluoromethyl)phenyl>-1,1,2,2-tetrafluoroethane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1,2-bis<4-(difluoromethyl)phenyl>-1,1,2,2-tetrafluoroethane

There total 5 articles about 1,2-bis<4-(difluoromethyl)phenyl>-1,1,2,2-tetrafluoroethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4,4'-benzildicarboxaldehyde (21514-63-6) → 1,2-bis<4-(difluoromethyl)phenyl>-1,1,2,2-tetrafluoroethane (13348-33-9)

Guidance literature:

With diethylamino-sulfur trifluoride; In benzene; at 75 ℃; for 15h;

DOI:10.1021/jo00059a038

Reference yield:

1,2-di(4-methylphenyl)-1,2-ethanedione (3457-48-5) → 1,2-bis<4-(difluoromethyl)phenyl>-1,1,2,2-tetrafluoroethane (13348-33-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 24 percent / HOAc, conc. H₂SO₄, CrO₃ / 1 h / 0 - 5 °C

2: 72 percent / 28percent HCl / tetrahydrofuran / 8 h / Ambient temperature

3: 76 percent / (diethylamino)sulfur trifluoride / benzene / 15 h / 75 °C

With chromium(VI) oxide; hydrogenchloride; diethylamino-sulfur trifluoride; sulfuric acid; acetic acid; In tetrahydrofuran; benzene;

DOI:10.1021/jo00059a038

Reference yield:

4,4'-dimethylbenzoin (1218-89-9) → 1,2-bis<4-(difluoromethyl)phenyl>-1,1,2,2-tetrafluoroethane (13348-33-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 81 percent / cupric sulfate pentahydrate, pyridine / H₂O / Heating

2: 24 percent / HOAc, conc. H₂SO₄, CrO₃ / 1 h / 0 - 5 °C

3: 72 percent / 28percent HCl / tetrahydrofuran / 8 h / Ambient temperature

4: 76 percent / (diethylamino)sulfur trifluoride / benzene / 15 h / 75 °C

With pyridine; chromium(VI) oxide; hydrogenchloride; diethylamino-sulfur trifluoride; sulfuric acid; copper(II) sulfate; acetic acid; In tetrahydrofuran; water; benzene;

DOI:10.1021/jo00059a038

upstream raw materials:

4,4'-benzildicarboxaldehyde

1,2-di(4-methylphenyl)-1,2-ethanedione

4,4'-dimethylbenzoin

4-methyl-benzaldehyde