4,4'-benzildicarboxaldehyde

Base Information

• Chemical Name: 4,4'-benzildicarboxaldehyde
• CAS No.: 21514-63-6
• Molecular Formula: C₁₆H₁₀O₄
• Molecular Weight: 266.253
• Mol file: 21514-63-6.mol

Synonyms:4,4'-benzildicarboxaldehyde

Chemical Property of 4,4'-benzildicarboxaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,4'-benzildicarboxaldehyde

There total 6 articles about 4,4'-benzildicarboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

p,p'-bis(diacetoxymethyl)benzil → 4,4'-benzildicarboxaldehyde (21514-63-6)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; for 8h; Ambient temperature;

DOI:10.1021/jo00059a038

Reference yield: 21.0%

4-bromobenzaldehyde diethyl acetal (34421-94-8) + 1,4-dimethyl-2,3-dioxopiperazine (59417-06-0) → 4,4'-benzildicarboxaldehyde (21514-63-6)

Guidance literature:

4-bromobenzaldehyde diethyl acetal; With n-butyllithium; In tetrahydrofuran; hexanes; at -78 ℃; for 1h;

1,4-dimethyl-2,3-dioxopiperazine; In tetrahydrofuran; hexanes; at -78 - 20 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; hexanes;

Reference yield:

1,2-di(4-methylphenyl)-1,2-ethanedione (3457-48-5) → 4,4'-benzildicarboxaldehyde (21514-63-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 24 percent / HOAc, conc. H₂SO₄, CrO₃ / 1 h / 0 - 5 °C

2: 72 percent / 28percent HCl / tetrahydrofuran / 8 h / Ambient temperature

With chromium(VI) oxide; hydrogenchloride; sulfuric acid; acetic acid; In tetrahydrofuran;

DOI:10.1021/jo00059a038

upstream raw materials:

1,2-di(4-methylphenyl)-1,2-ethanedione

4,4'-dimethylbenzoin

4-methyl-benzaldehyde

α,α'-dibromotolil

Downstream raw materials:

1,2-bis<4-(difluoromethyl)phenyl>-1,1,2,2-tetrafluoroethane