N⁶-[1-(3,4-Dichloro-phenyl)-ethyl]-N⁶-methyl-pyrido[3,2-d]pyrimidine-2,4,6-triamine

Base Information

• Chemical Name: N⁶-[1-(3,4-Dichloro-phenyl)-ethyl]-N⁶-methyl-pyrido[3,2-d]pyrimidine-2,4,6-triamine
• CAS No.: 93684-01-6
• Molecular Formula: C₁₆H₁₆Cl₂N₆
• Molecular Weight: 363.249

Synonyms:N⁶-[1-(3,4-Dichloro-phenyl)-ethyl]-N⁶-methyl-pyrido[3,2-d]pyrimidine-2,4,6-triamine

Chemical Property of N⁶-[1-(3,4-Dichloro-phenyl)-ethyl]-N⁶-methyl-pyrido[3,2-d]pyrimidine-2,4,6-triamine

Chemical Property:

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Technology Process of N⁶-[1-(3,4-Dichloro-phenyl)-ethyl]-N⁶-methyl-pyrido[3,2-d]pyrimidine-2,4,6-triamine

There total 4 articles about N⁶-[1-(3,4-Dichloro-phenyl)-ethyl]-N⁶-methyl-pyrido[3,2-d]pyrimidine-2,4,6-triamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

chloroformamidine hydrochloride (29671-92-9) + 3-Amino-6-{[1-(3,4-dichloro-phenyl)-ethyl]-methyl-amino}-pyridine-2-carbonitrile (93683-89-7) → N6-[1-(3,4-Dichloro-phenyl)-ethyl]-N6-methyl-pyrido[3,2-d]pyrimidine-2,4,6-triamine (93684-01-6)

Guidance literature:

In dimethyl sulfoxide; at 125 ℃; for 1.5h;

DOI:10.1021/jm00380a018

Reference yield:

[1-(3,4-dichlorophenyl)ethyl]methylamine (40023-76-5) → N6-[1-(3,4-Dichloro-phenyl)-ethyl]-N6-methyl-pyrido[3,2-d]pyrimidine-2,4,6-triamine (93684-01-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 63 percent / Et₃N / 2-ethoxy-ethanol / 1 h / Heating

2: 63 percent / Fe, conc. aq. HCl / 1 h / Heating

3: 43 percent / dimethylsulfoxide / 1.5 h / 125 °C

With hydrogenchloride; iron; triethylamine; In 2-ethoxy-ethanol; dimethyl sulfoxide;

DOI:10.1021/jm00380a018

Reference yield:

6-chloro-3-nitropicolinonitrile (93683-65-9) → N6-[1-(3,4-Dichloro-phenyl)-ethyl]-N6-methyl-pyrido[3,2-d]pyrimidine-2,4,6-triamine (93684-01-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 63 percent / Et₃N / 2-ethoxy-ethanol / 1 h / Heating

2: 63 percent / Fe, conc. aq. HCl / 1 h / Heating

3: 43 percent / dimethylsulfoxide / 1.5 h / 125 °C

With hydrogenchloride; iron; triethylamine; In 2-ethoxy-ethanol; dimethyl sulfoxide;

DOI:10.1021/jm00380a018

upstream raw materials:

chloroformamidine hydrochloride

3-Amino-6-{[1-(3,4-dichloro-phenyl)-ethyl]-methyl-amino}-pyridine-2-carbonitrile

[1-(3,4-dichlorophenyl)ethyl]methylamine

6-chloro-3-nitropicolinonitrile

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