2-Azaadenosine

Base Information

• Chemical Name: 2-Azaadenosine
• CAS No.: 146-94-1
• Molecular Formula: C₉H₁₂N₆O₄
• Molecular Weight: 268.232
• Nikkaji Number: J1.302.689K
• ChEMBL ID: CHEMBL173003
• Mol file: 146-94-1.mol

Synonyms:2-azaadenosine

Chemical Property of 2-Azaadenosine

Chemical Property:

• Vapor Pressure: 1.81E-22mmHg at 25°C
• Boiling Point: 731.6°Cat760mmHg
• Flash Point: 396.3°C
• PSA: 152.43000
• Density: 2.29g/cm³
• LogP: -2.00380
• XLogP3: -2
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 2
• Exact Mass: 268.09200289
• Heavy Atom Count: 19
• Complexity: 336

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=NC2=C(N=NN=C2N1C3C(C(C(O3)CO)O)O)N
• Isomeric SMILES: C1=NC2=C(N=NN=C2N1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N

Technology Process of 2-Azaadenosine

There total 10 articles about 2-Azaadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4-amino-7-[2,3,5-tri-O-(t-butyldimethylsilyl)-β-D-ribofuranosyl]imidazo[4,5-d][1,2,3]triazine (270065-11-7) → 2-Azaadenosine (146-94-1)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.5h;

DOI:10.1080/15257770008032996

Reference yield: 55.0%

4-methoxy-7-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)imidazo[4,5-d][1,2,3]triazine (270065-08-2) → 2-Azaadenosine (146-94-1)

Guidance literature:

With ammonia; In methanol; for 72h;

DOI:10.1080/15257770008032996

Reference yield: 35.0%

4-(1,2,4-triazol-1-yl)-7-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)imidazo[4,5-d][1,2,3]triazine → 2-Azaadenosine (146-94-1)

Guidance literature:

With ammonia; In methanol; for 72h;

DOI:10.1080/15257770008032996

upstream raw materials:

4-methoxy-7-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)imidazo[4,5-d][1,2,3]triazine

4-amino-7-[2,3,5-tri-O-(t-butyldimethylsilyl)-β-D-ribofuranosyl]imidazo[4,5-d][1,2,3]triazine

7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,7-dihydro-4H-imidazo[4,5-d][1,2,3]triazin-4-one

7-(2,3,5,-tri-O-acetyl-β-D-ribofuranosyl)imidazo[4,5-d][1,2,3]triazin-4-one

Refernces