2-azido-3-phenylpyrazine

Base Information

• Chemical Name: 2-azido-3-phenylpyrazine
• CAS No.: 156331-29-2
• Molecular Formula: C₁₀H₇N₅
• Molecular Weight: 197.199
• Mol file: 156331-29-2.mol

Synonyms:2-azido-3-phenylpyrazine

Chemical Property of 2-azido-3-phenylpyrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-azido-3-phenylpyrazine

There total 3 articles about 2-azido-3-phenylpyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-chloro-3-phenylpyrazine (41270-65-9) → 2-azido-3-phenylpyrazine (156331-29-2)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 85 ℃; for 8h;

DOI:10.1055/s-1994-25607

Reference yield:

2-phenylpyrazine (29460-97-7) → 2-azido-3-phenylpyrazine (156331-29-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / m-chloroperbenzoic acid (87percent) / 1,2-dichloro-ethane / 24 h / Ambient temperature

2: trimethylsilyl azide, diethylcarbamoyl chloride / acetonitrile / 30 h / Heating

With trimethylsilylazide; N,N-diethylcarbamyl chloride; 3-chloro-benzenecarboperoxoic acid; In 1,2-dichloro-ethane; acetonitrile;

Reference yield:

2-phenylpyrazine 4-oxide (58861-94-2) → 2-azido-5-phenylpyrazine + 2-azido-3-phenylpyrazine (156331-29-2)

Guidance literature:

With trimethylsilylazide; N,N-diethylcarbamyl chloride; In acetonitrile; for 30h; Yield given. Yields of byproduct given; Heating;

upstream raw materials:

2-chloro-3-phenylpyrazine

2-phenylpyrazine 4-oxide

2-phenylpyrazine

Downstream raw materials:

2-Amino-3-phenylpyrazine