3-Phenylpyrazin-2-amine

Base Information

• Chemical Name: 3-Phenylpyrazin-2-amine
• CAS No.: 41270-67-1
• Molecular Formula: C10H9N3
• Molecular Weight: 171.202
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID50543058
• Nikkaji Number: J613.436J
• Wikidata: Q82419890
• Mol file: 41270-67-1.mol

Synonyms:2-amino-3-phenylpyrazine

Chemical Property of 3-Phenylpyrazin-2-amine

Chemical Property:

• PSA: 41.62000
• LogP: 1.21000
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 171.079647300
• Heavy Atom Count: 13
• Complexity: 154

Purity/Quality:

97% ^*data from raw suppliers

3-phenylpyrazin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=NC=CN=C2N

Technology Process of 3-Phenylpyrazin-2-amine

There total 5 articles about 3-Phenylpyrazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

2-azido-3-phenylpyrazine (156331-29-2) → 2-Amino-3-phenylpyrazine (41270-67-1)

Guidance literature:

With hydrogenchloride; tin(ll) chloride; In methanol; at 60 ℃; for 4h;

DOI:10.1055/s-1994-25607

Reference yield:

3-bromo-pyrazine-2-amine (21943-12-4) + phenylboronic acid (98-80-6) → 2-Amino-3-phenylpyrazine (41270-67-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In toluene; at 120 ℃; for 12h;

Reference yield:

trimethylsilyl cyanide (7677-24-9) + benzaldehyde (100-52-7) + ethylenediamine (107-15-3,85404-18-8) → 2-Amino-3-phenylpyrazine (41270-67-1)

Guidance literature:

benzaldehyde; ethylenediamine; In 1,4-dioxane; at 70 ℃; for 0.25h;

trimethylsilyl cyanide; With oxygen; 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; at 25 - 27 ℃; for 3h;

With manganese(IV) oxide; potassium hydroxide; In 1,4-dioxane; methanol; at 25 - 27 ℃;

DOI:10.1039/c6ra12028h

upstream raw materials:

2-azido-3-phenylpyrazine

2-chloro-3-phenylpyrazine

trimethylsilyl cyanide

benzaldehyde

Downstream raw materials:

1-Oxy-3-phenyl-pyrazin-2-ylamine

5-bromo-3-phenyl-pyrazin-2-amine

2-Benzamido-3-phenylpyrazine