41270-65-9

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
2-Chloro-3-phenylpyrazine serves as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its unique molecular structure and reactivity make it a valuable component in the production of organic compounds with therapeutic or pesticidal properties.
Used in Flavor and Fragrance Industry:
Leveraging its aromatic properties, 2-Chloro-3-phenylpyrazine is employed in the flavor and fragrance industry to create unique scents and flavors for various consumer products.
Used in Insecticide Development:
2-Chloro-3-phenylpyrazine has been studied for its potential as an insecticide, with research exploring its ability to effectively control and manage insect populations.
Used in Anticancer Research:
As a potential anticancer agent, 2-Chloro-3-phenylpyrazine is under investigation for its biological activities that may contribute to the development of novel cancer treatments. Its specific mechanisms of action and potential synergistic effects with existing therapies are areas of ongoing research.

Upstream product

• 2882-18-0 3-phenyl-2(1H)-pyrazinone 
• 2882-18-0 2-hydroxy-3-phenylpyrazine 
• 58861-89-5 2-phenylpyrazine N⁽¹⁾-oxide 
• 58861-94-2 2-phenylpyrazine 4-oxide 
• 66769-58-2 3-chloro-2-phenylpyrazine-1-oxide 
• 14508-49-7 2-chloropyrazin 
• 591-50-4 iodobenzene 
• 243472-81-3 2-phenyl-3-trimethylsilanyloxy-pyrazine 
• 1074-12-0 phenylglyoxal hydrate 
• 160315-09-3 2-acetoxy-3-phenylpyrazine 
• 29460-97-7 2-phenylpyrazine 
• 58861-87-3 2-chloro-3-phenyl-pyrazine 4-oxide 
• 100-34-5 benzene diazonium chloride 
• 4858-85-9 2,3-dichloropyrazine 

Downstream Products

• 99984-63-1 2-methoxy-3-phenylpyrazine 
• 17705-33-8 3-phenylpyrazine-2-thiol 
• 58861-88-4 2-chloro-3-phenylpyrazine 1,4-dioxide 
• 58861-87-3 2-chloro-3-phenyl-pyrazine 4-oxide 
• 156331-29-2 2-azido-3-phenylpyrazine 
• 41270-67-1 2-Amino-3-phenylpyrazine 
• 32493-80-4 2,3-dichloro-5-phenylpyrazine 
• 64163-09-3 2,5-dichloro-6-phenylpyrazine 
• 76809-46-6 2-hydroxy-6-phenylpyrazine 4-oxide 
• 85093-94-3 2-hydroxy-3-phenylpyrazine 4-oxide 
• 160315-17-3 2-acetoxy-6-phenylpyrazine 
• 160315-09-3 2-acetoxy-3-phenylpyrazine 
• 85093-95-4 3,5-dichloro-2-phenylpyrazine 1-oxide 
• 41270-62-6 2-chloro-6-phenylpyrazine 

Relevant academic research and scientific papers

SIGMA-1 RECEPTOR LIGANDS AND THERAPEUTIC USES THEREOF

The present invention relates to the field of medicine. More specifically, the present invention relates to compounds that are sigma-1 receptor agonists and their use for the treatment of central nervous system disorders, including cognitive or neurodegen

Stereodivergent Photoelectrocyclization Reactions of Bis-aryl Cycloalkenones: Intercepting Photoelectrocyclization Intermediates with Acid

Described here are tandem photoelectrocyclization and [1,5]-hydride shift reactions of heteroaryl-containing bis-aryl cyclohexenone derivatives that give heteroaryl-substituted dihydrophenanthrenes. This Letter demonstrates that electrocyclization intermediates can be trapped with acid when the [1,5]-hydride shift is relatively slow. From a practical perspective, the observation that the acid-mediated reaction gives a divergent stereochemical outcome when compared with the reaction run under neutral conditions makes these transformations powerful.

N - acyl - [...] P 2X7 adjustment

The present invention is directed to compounds of Formula (I), which includes enantiomer and diasteromers thereof: These compounds are suitable for use in the treatment of diseases associated with P2X7 receptor activity such as diseases of the autoimmune

Novel Phenyl-Substituted 5,6-Dihydro-[1,2,4]triazolo[4,3-a]pyrazine P2X7 Antagonists with Robust Target Engagement in Rat Brain

Novel 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine P2X7 antagonists were optimized to allow for good blood-brain barrier permeability and high P2X7 target engagement in the brain of rats. Compound 25 (huP2X7 IC50 = 9 nM; rat P2X7 IC50

Studies on pyrazines. 35 [1]. An improved synthesis of bromopyrazines from hydroxypyrazines

The synthesis of bromopyrazines from hydroxypyrazines was successfully effected by the procedure via trimethylsilyloxypyrazines, the sequence of which proceeds under mild conditions and does not require the isolation of intermediate.

Organozinc derivatives of diazines, metalation of diazines XXIII

Some organozinc derivatives of diazines have been prepared from lithiated diazines and zinc chloride. They reacted in cross coupling reactions with iodobenzene, 2-bromopyridine and 5-bromopyrimidine. The use of sonication, for the first time in a Negishi reaction, lowered the reaction times significantly and improved the yields.

Novel (substituted phenyl)-1,2,4-triazolo (4,3-A)pyrazines and novel 2-hydrazino-(substituted phenyl)pyrazine intermediates

This disclosure describes novel 5-,6- and 8-(phenyl and substituted phenyl)-1,2,4-triazolo[4,3-a]pyrazines which posses utility as anxiolytic agents.

Some Reactions of Mono Substituted Pyrazine Monoxides

The reactions of the monoxides of propylpyrazine and phenylpyrazine with phosphoryl chloride or acetic anhydride were investigated.Except in the case of the reaction of 2-propylpyrazine 1-oxide with acetic anhydride, chlorination or acetoxylation occurred