tert-butyl 4-((4-(methoxycarbonyl)benzyl)amino)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-((4-(methoxycarbonyl)benzyl)amino)piperidine-1-carboxylate
• CAS No.: 888944-34-1
• Molecular Formula: C₁₉H₂₈N₂O₄
• Molecular Weight: 348.442

Synonyms:tert-butyl 4-((4-(methoxycarbonyl)benzyl)amino)piperidine-1-carboxylate

Chemical Property of tert-butyl 4-((4-(methoxycarbonyl)benzyl)amino)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

tert-Butyl4-[4-(methoxycarbonyl)benzylamino]piperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

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Technology Process of tert-butyl 4-((4-(methoxycarbonyl)benzyl)amino)piperidine-1-carboxylate

There total 2 articles about tert-butyl 4-((4-(methoxycarbonyl)benzyl)amino)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-(tert-butoxycarbonyl)-4-aminopiperidine (87120-72-7) + methyl 4-formylbenzoate (1571-08-0) → tert-butyl 4-((4-(methoxycarbonyl)benzyl)amino)piperidine-1-carboxylate (888944-34-1)

Guidance literature:

1-(tert-butoxycarbonyl)-4-aminopiperidine; methyl 4-formylbenzoate; With triethylamine; In methanol; for 4h; Heating / reflux;

With sodium tetrahydroborate; at 20 ℃; for 1h;

Reference yield: 75.0%

Methyl 4-(bromomethyl)benzoate (2417-72-3) + 1-(tert-butoxycarbonyl)-4-aminopiperidine (87120-72-7) → tert-butyl 4-((4-(methoxycarbonyl)benzyl)amino)piperidine-1-carboxylate (888944-34-1)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 18h;

Reference yield: 77.0%

tert-butyl 4-((4-(methoxycarbonyl)benzyl)amino)piperidine-1-carboxylate (888944-34-1) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 4-((tert-butoxycarbonyl) (4-(methoxycarbonyl) benzyl)amino)piperidine-1-carboxylate

Guidance literature:

tert-butyl 4-((4-(methoxycarbonyl)benzyl)amino)piperidine-1-carboxylate; With potassium carbonate; In methanol; water; Cooling with ice;

di-tert-butyl dicarbonate; In tetrahydrofuran; methanol; water; at 20 ℃; Cooling with ice;

DOI:10.1016/j.bmcl.2016.05.067

upstream raw materials:

1-(tert-butoxycarbonyl)-4-aminopiperidine

methyl 4-formylbenzoate

Methyl 4-(bromomethyl)benzoate

Downstream raw materials:

C₃₁H₄₂N₂O₅

4-[(1-{(S)-2-[(R)-2-cyclopentylmethyl-3-(formyl-hydroxy-amino)-propionylamino]-3,3-dimethyl-butyryl}-piperidin-4-ylamino)-methyl]-benzoic acid methyl ester

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