3-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)-3-oxopropanoic acid

Base Information

• Chemical Name: 3-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)-3-oxopropanoic acid
• CAS No.: 53943-72-9
• Molecular Formula: C₁₃H₂₂O₄
• Molecular Weight: 242.315
• Mol file: 53943-72-9.mol

Synonyms:3-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)-3-oxopropanoic acid

Chemical Property of 3-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)-3-oxopropanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)-3-oxopropanoic acid

There total 7 articles about 3-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)-3-oxopropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

cycl-isopropylidene malonate (2033-24-1) + (-)-menthol (2216-51-5) → 3-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)-3-oxopropanoic acid (53943-72-9)

Guidance literature:

In toluene; for 20h; Reflux;

DOI:10.1016/j.molliq.2019.112003

Reference yield: 21.0%

malonic acid (141-82-2) + (-)-menthol (2216-51-5) → 3-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)-3-oxopropanoic acid (53943-72-9)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In chloroform; at 20 ℃; for 8h;

DOI:10.1016/j.ejmech.2010.01.037

Reference yield:

Malonic acid tert-butyl ester (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester (67406-69-3) → 3-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)-3-oxopropanoic acid (53943-72-9)

Guidance literature:

With triethylamine tris(hydrogen fluoride); In dichloromethane;

DOI:10.1016/j.tetlet.2005.05.044

upstream raw materials:

di-l-menthyl malonate

(-)-menthol

malonoyl dichloride

Malonic acid tert-butyl ester (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Downstream raw materials:

(S)-3-hydroxy-3-phenylpropanoic acid

N-Boc-N'-((menthoxycarbonyl)acetyl)hydrazine