(R)-2-(7-benzyloxycarbamoyl-heptanoylamino)-3-phenylpropionic acid methyl ester

Base Information

Chemical Name:(R)-2-(7-benzyloxycarbamoyl-heptanoylamino)-3-phenylpropionic acid methyl ester
CAS No.:449728-91-0
Molecular Formula:C₂₅H₃₂N₂O₅
Molecular Weight:440.539
Hs Code.:

Synonyms:(R)-2-(7-benzyloxycarbamoyl-heptanoylamino)-3-phenylpropionic acid methyl ester

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Chemical Property of (R)-2-(7-benzyloxycarbamoyl-heptanoylamino)-3-phenylpropionic acid methyl ester

Chemical Property:

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Technology Process of (R)-2-(7-benzyloxycarbamoyl-heptanoylamino)-3-phenylpropionic acid methyl ester

There total 4 articles about (R)-2-(7-benzyloxycarbamoyl-heptanoylamino)-3-phenylpropionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 13033-84-6
D-phenylalanine methyl ester hydrochloride

: 251304-81-1
8-((benzyloxy)amino)-8-oxooctanoic acid

: 449728-91-0
(R)-2-(7-benzyloxycarbamoyl-heptanoylamino)-3-phenylpropionic acid methyl ester

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/jm0208119

Reference yield:

: 3946-32-5
suberic acid monomethyl ester

: 449728-91-0
(R)-2-(7-benzyloxycarbamoyl-heptanoylamino)-3-phenylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / iPr₂NEt; BOP-Cl / CH₂Cl₂

2: 68 percent / aq. LiOH / tetrahydrofuran / 20 °C

3: 69 percent / iPr₂NEt; BOP-Cl / CH₂Cl₂

With lithium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm0208119

Reference yield:

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 449728-91-0
(R)-2-(7-benzyloxycarbamoyl-heptanoylamino)-3-phenylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / iPr₂NEt; BOP-Cl / CH₂Cl₂

2: 68 percent / aq. LiOH / tetrahydrofuran / 20 °C

3: 69 percent / iPr₂NEt; BOP-Cl / CH₂Cl₂

With lithium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm0208119