rac-2-[(2-benzyloxyethyl)-thyminacetyl-amino]-cyclohexancarboxylic acid-(4-tert-butyl-cyclohexen-1-yl)-amide

Base Information

• Chemical Name: rac-2-[(2-benzyloxyethyl)-thyminacetyl-amino]-cyclohexancarboxylic acid-(4-tert-butyl-cyclohexen-1-yl)-amide
• CAS No.: 292072-97-0
• Molecular Formula: C₃₃H₄₆N₄O₅
• Molecular Weight: 578.752
• Mol file: 292072-97-0.mol

Synonyms:rac-2-[(2-benzyloxyethyl)-thyminacetyl-amino]-cyclohexancarboxylic acid-(4-tert-butyl-cyclohexen-1-yl)-amide

Chemical Property of rac-2-[(2-benzyloxyethyl)-thyminacetyl-amino]-cyclohexancarboxylic acid-(4-tert-butyl-cyclohexen-1-yl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of rac-2-[(2-benzyloxyethyl)-thyminacetyl-amino]-cyclohexancarboxylic acid-(4-tert-butyl-cyclohexen-1-yl)-amide

There total 3 articles about rac-2-[(2-benzyloxyethyl)-thyminacetyl-amino]-cyclohexancarboxylic acid-(4-tert-butyl-cyclohexen-1-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

thymidyl acetic acid (20924-05-4) + O-benzylethanolamine (38336-04-8) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + rac-4-tert-butyl-cyclohexen-1-yl-isocyanide (223252-57-1) → rac-2-[(2-benzyloxyethyl)-thyminacetyl-amino]-cyclohexancarboxylic acid-(4-tert-butyl-cyclohexen-1-yl)-amide (292072-97-0)

Guidance literature:

In methanol; at 20 ℃; for 48h;

DOI:10.1016/S0968-0896(00)00066-3

Reference yield:

4-tercbutyl-cyclohexanone (98-53-3) → rac-2-[(2-benzyloxyethyl)-thyminacetyl-amino]-cyclohexancarboxylic acid-(4-tert-butyl-cyclohexen-1-yl)-amide (292072-97-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / aq. H₂SO₄ / toluene / 12 h / Heating; Dean-Stark-conditions

2: 80 percent / phosgene; NEt₃ / CH₂Cl₂ / 1 h / 0 °C

3: 81 percent / methanol / 48 h / 20 °C

With phosgene; sulfuric acid; triethylamine; In methanol; dichloromethane; toluene; 1: Condensation / 2: Dehydration / 3: Ugi four component condensation;

DOI:10.1016/S0968-0896(00)00066-3

Reference yield:

rac-N-4-tert-butyl-cyclohex-1-enyl-formamide (255735-91-2) → rac-2-[(2-benzyloxyethyl)-thyminacetyl-amino]-cyclohexancarboxylic acid-(4-tert-butyl-cyclohexen-1-yl)-amide (292072-97-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / phosgene; NEt₃ / CH₂Cl₂ / 1 h / 0 °C

2: 81 percent / methanol / 48 h / 20 °C

With phosgene; triethylamine; In methanol; dichloromethane; 1: Dehydration / 2: Ugi four component condensation;

DOI:10.1016/S0968-0896(00)00066-3

upstream raw materials:

thymidyl acetic acid

O-benzylethanolamine

cyclohexanone

rac-4-tert-butyl-cyclohexen-1-yl-isocyanide