(2S,3S)-3-Azido-2-(2,4-dichloro-phenyl)-1-[1,2,4]triazol-1-yl-butan-2-ol

Base Information

• Chemical Name: (2S,3S)-3-Azido-2-(2,4-dichloro-phenyl)-1-[1,2,4]triazol-1-yl-butan-2-ol
• CAS No.: 132563-75-8
• Molecular Formula: C₁₂H₁₂Cl₂N₆O
• Molecular Weight: 327.173
• Mol file: 132563-75-8.mol

Synonyms:(2S,3S)-3-Azido-2-(2,4-dichloro-phenyl)-1-[1,2,4]triazol-1-yl-butan-2-ol

Chemical Property of (2S,3S)-3-Azido-2-(2,4-dichloro-phenyl)-1-[1,2,4]triazol-1-yl-butan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3S)-3-Azido-2-(2,4-dichloro-phenyl)-1-[1,2,4]triazol-1-yl-butan-2-ol

There total 2 articles about (2S,3S)-3-Azido-2-(2,4-dichloro-phenyl)-1-[1,2,4]triazol-1-yl-butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

Methanesulfonic acid (1S,2S)-2-(2,4-dichloro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl ester (132563-74-7) → (2S,3S)-3-Azido-2-(2,4-dichloro-phenyl)-1-[1,2,4]triazol-1-yl-butan-2-ol (132563-75-8)

Guidance literature:

With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 115 ℃; for 15h;

DOI:10.1248/cpb.38.2476

Reference yield:

(2S,3S)-2-(2,4-Dichloro-phenyl)-1-[1,2,4]triazol-1-yl-butane-2,3-diol (132563-72-5) → (2S,3S)-3-Azido-2-(2,4-dichloro-phenyl)-1-[1,2,4]triazol-1-yl-butan-2-ol (132563-75-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / pyridine / 2 h / Ambient temperature

2: 88 percent / NaN₃, NH₄Cl / dimethylformamide / 15 h / 115 °C

With pyridine; sodium azide; ammonium chloride; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.38.2476

Reference yield: 100.0%

(2S,3S)-3-Azido-2-(2,4-dichloro-phenyl)-1-[1,2,4]triazol-1-yl-butan-2-ol (132563-75-8) → (2S,3S)-3-Amino-2-(2,4-dichloro-phenyl)-1-[1,2,4]triazol-1-yl-butan-2-ol (132563-80-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 1h;

DOI:10.1248/cpb.38.2476

upstream raw materials:

Methanesulfonic acid (1S,2S)-2-(2,4-dichloro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl ester

(2S,3S)-2-(2,4-Dichloro-phenyl)-1-[1,2,4]triazol-1-yl-butane-2,3-diol

Downstream raw materials:

(2S,3S)-3-Amino-2-(2,4-dichloro-phenyl)-1-[1,2,4]triazol-1-yl-butan-2-ol

1-[(4S,5S)-5-(2,4-Dichloro-phenyl)-4-methyl-oxazolidin-5-ylmethyl]-1H-[1,2,4]triazole

(4-Chloro-phenyl)-[(4S,5S)-5-(2,4-dichloro-phenyl)-4-methyl-5-[1,2,4]triazol-1-ylmethyl-oxazolidin-3-yl]-methanone