Methanesulfonic acid (1S,2S)-2-(2,4-dichloro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl ester

Base Information

• Chemical Name: Methanesulfonic acid (1S,2S)-2-(2,4-dichloro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl ester
• CAS No.: 132563-74-7
• Molecular Formula: C₁₃H₁₅Cl₂N₃O₄S
• Molecular Weight: 380.252

Synonyms:Methanesulfonic acid (1S,2S)-2-(2,4-dichloro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl ester

Chemical Property of Methanesulfonic acid (1S,2S)-2-(2,4-dichloro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl ester

Chemical Property:

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Technology Process of Methanesulfonic acid (1S,2S)-2-(2,4-dichloro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl ester

There total 2 articles about Methanesulfonic acid (1S,2S)-2-(2,4-dichloro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(2R,3R)-2-(2,4-Dichloro-phenyl)-1-[1,2,4]triazol-1-yl-butane-2,3-diol (126916-49-2,127181-87-7,132563-72-5) + methanesulfonyl chloride (124-63-0) → Methanesulfonic acid (1S,2S)-2-(2,4-dichloro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl ester (126916-48-1,127181-89-9,132563-74-7)

Guidance literature:

With pyridine; for 2h; Ambient temperature;

DOI:10.1248/cpb.38.2476

Reference yield: 93.0%

(2S,3S)-2-(2,4-Dichloro-phenyl)-1-[1,2,4]triazol-1-yl-butane-2,3-diol (132563-72-5) + methanesulfonyl chloride (124-63-0) → Methanesulfonic acid (1S,2S)-2-(2,4-dichloro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl ester (132563-74-7)

Guidance literature:

With pyridine; for 2h; Ambient temperature;

DOI:10.1248/cpb.38.2476

Reference yield: 88.0%

Methanesulfonic acid (1S,2S)-2-(2,4-dichloro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl ester (132563-74-7) → (2S,3S)-3-Azido-2-(2,4-dichloro-phenyl)-1-[1,2,4]triazol-1-yl-butan-2-ol (132563-75-8)

Guidance literature:

With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 115 ℃; for 15h;

DOI:10.1248/cpb.38.2476

upstream raw materials:

(2S,3S)-2-(2,4-Dichloro-phenyl)-1-[1,2,4]triazol-1-yl-butane-2,3-diol

methanesulfonyl chloride

(2R,3R)-2-(2,4-Dichloro-phenyl)-1-[1,2,4]triazol-1-yl-butane-2,3-diol

Downstream raw materials:

1-[(2S,3R)-2-(2,4-Dichloro-phenyl)-3-methyl-oxiranylmethyl]-1H-[1,2,4]triazole

(2S,3S)-3-Azido-2-(2,4-dichloro-phenyl)-1-[1,2,4]triazol-1-yl-butan-2-ol

(2S,3S)-3-Amino-2-(2,4-dichloro-phenyl)-1-[1,2,4]triazol-1-yl-butan-2-ol

1-[(4S,5S)-5-(2,4-Dichloro-phenyl)-4-methyl-oxazolidin-5-ylmethyl]-1H-[1,2,4]triazole

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