methyl 2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5'-cyano-6,2'-dimethoxybiphenyl-3-yl]-2-methylpropanoate

Base Information

• Chemical Name: methyl 2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5'-cyano-6,2'-dimethoxybiphenyl-3-yl]-2-methylpropanoate
• CAS No.: 871822-53-6
• Molecular Formula: C₂₈H₂₇N₅O₄
• Molecular Weight: 497.553
• Mol file: 871822-53-6.mol

Synonyms:methyl 2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5'-cyano-6,2'-dimethoxybiphenyl-3-yl]-2-methylpropanoate

Chemical Property of methyl 2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5'-cyano-6,2'-dimethoxybiphenyl-3-yl]-2-methylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5'-cyano-6,2'-dimethoxybiphenyl-3-yl]-2-methylpropanoate

There total 13 articles about methyl 2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5'-cyano-6,2'-dimethoxybiphenyl-3-yl]-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-(5'-cyano-5-formyl-6,2'-dimethoxybiphenyl-3-yl)-2-methylpropanoate (871822-52-5) + 3,4-diaminobenzamidine monohydrochloride → methyl 2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5'-cyano-6,2'-dimethoxybiphenyl-3-yl]-2-methylpropanoate (871822-53-6)

Guidance literature:

methyl 2-(5'-cyano-5-formyl-6,2'-dimethoxybiphenyl-3-yl)-2-methylpropanoate; With sodium disulfite; In water; isopropyl alcohol; at 70 ℃; for 1.5h;

3,4-diaminobenzamidine monohydrochloride; In water; isopropyl alcohol; at 75 - 80 ℃;

Reference yield:

methyl 2-(3-formyl-4-hydroxyphenyl)-2-methylpropanoate (731015-44-4) → methyl 2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5'-cyano-6,2'-dimethoxybiphenyl-3-yl]-2-methylpropanoate (871822-53-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide / DMF (N,N-dimethyl-formamide) / 3 h / 5 - 20 °C

2.1: potassium carbonate / DMF (N,N-dimethyl-formamide) / 3.5 h / 20 °C

3.1: diisopropylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 20 - 70 °C

4.1: sodium disulfite / water; isopropyl alcohol / 1.5 h / 70 °C

4.2: 75 - 80 °C

With sodium disulfite; N-Bromosuccinimide; potassium carbonate; diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); water; isopropyl alcohol;

Reference yield:

4-amino-3-nitrobenzamidine monohydrochloride (74138-37-7) → methyl 2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5'-cyano-6,2'-dimethoxybiphenyl-3-yl]-2-methylpropanoate (871822-53-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogen / palladium hydroxide on carbon / methanol / 1.5 h / 2585.81 Torr

2.1: sodium disulfite / water; isopropyl alcohol / 1.5 h / 70 °C

2.2: 75 - 80 °C

With sodium disulfite; hydrogen; palladium hydroxide on carbon; In methanol; water; isopropyl alcohol;

upstream raw materials:

methyl 2-(5'-cyano-5-formyl-6,2'-dimethoxybiphenyl-3-yl)-2-methylpropanoate

4-amino-3-nitrobenzamidine monohydrochloride

methyl 2-(3-formyl-4-hydroxyphenyl)-2-methylpropanoate

methyl 2-(3-bromo-5-formyl-4-hydroxy-phenyl)-2-methyl-propionate