methyl 2-(3-bromo-5-formyl-4-hydroxy-phenyl)-2-methyl-propionate

Base Information

• Chemical Name: methyl 2-(3-bromo-5-formyl-4-hydroxy-phenyl)-2-methyl-propionate
• CAS No.: 731015-45-5
• Molecular Formula: C₁₂H₁₃BrO₄
• Molecular Weight: 301.137
• Mol file: 731015-45-5.mol

Synonyms:methyl 2-(3-bromo-5-formyl-4-hydroxy-phenyl)-2-methyl-propionate

Chemical Property of methyl 2-(3-bromo-5-formyl-4-hydroxy-phenyl)-2-methyl-propionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(3-bromo-5-formyl-4-hydroxy-phenyl)-2-methyl-propionate

There total 5 articles about methyl 2-(3-bromo-5-formyl-4-hydroxy-phenyl)-2-methyl-propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

methyl 2-(3-formyl-4-hydroxyphenyl)-2-methylpropanoate (731015-44-4) → methyl 2-(3-bromo-5-formyl-4-hydroxy-phenyl)-2-methyl-propionate (731015-45-5)

Guidance literature:

With N-Bromosuccinimide; In DMF (N,N-dimethyl-formamide); for 3h;

Reference yield:

2-(4-methoxyphenyl)-2-methylpropanoic acid (2955-46-6) → methyl 2-(3-bromo-5-formyl-4-hydroxy-phenyl)-2-methyl-propionate (731015-45-5)

Guidance literature:

Multi-step reaction with 4 steps

1: Py*HCl / 180 °C

2: SOCl₂

3: MgCl₂; Et₃N / acetonitrile / Heating

4: N-bromosuccinamide / dimethylformamide

With thionyl chloride; N-bromosuccinamide; pyridine hydrochloride; triethylamine; magnesium chloride; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.bmcl.2006.06.016

Reference yield:

2-methyl-2-(p-hydroxyphenyl)-propionic acid (29913-51-7) → methyl 2-(3-bromo-5-formyl-4-hydroxy-phenyl)-2-methyl-propionate (731015-45-5)

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂

2: MgCl₂; Et₃N / acetonitrile / Heating

3: N-bromosuccinamide / dimethylformamide

With thionyl chloride; N-bromosuccinamide; triethylamine; magnesium chloride; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.bmcl.2006.06.016

upstream raw materials:

methyl 2-(3-formyl-4-hydroxyphenyl)-2-methylpropanoate

2-(4-methoxyphenyl)-2-methylpropanoic acid

2-methyl-2-(p-hydroxyphenyl)-propionic acid

2-(4-methoxy-phenyl)-2-methyl-propionitrile

Downstream raw materials:

(2S)-{2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]-2-methylpropionylamino}succinamide

methyl 2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5'-cyano-6,2'-dimethoxybiphenyl-3-yl]-2-methylpropanoate

2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]-2-methylpropionic acid

methyl 2-(3-bromo-5-formyl-4-methoxyphenyl)-2-methyl-propionate