731015-44-4

Upstream product

• 50-00-0 formaldehyd 
• 123342-40-5 methyl 2-(4-hydroxyphenyl)-2-methylpropanoate 
• 2955-46-6 2-(4-methoxyphenyl)-2-methylpropanoic acid 
• 29913-51-7 2-methyl-2-(p-hydroxyphenyl)-propionic acid 
• 5351-07-5 2-(4-methoxy-phenyl)-2-methyl-propionitrile 
• 100-97-0 hexamethylenetetramine 
• 6274-50-6 methyl 2-(4-methoxyphenyl)-2-methylpropanoate 

Downstream Products

• 871822-60-5 (2S)-{2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]-2-methylpropionylamino}succinamide 
• 871822-53-6 methyl 2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-5'-cyano-6,2'-dimethoxybiphenyl-3-yl]-2-methylpropanoate 
• 731015-35-3 2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]-2-methylpropionic acid 
• 731016-03-8 methyl 2-(3-bromo-5-formyl-4-methoxyphenyl)-2-methyl-propionate 
• 909036-44-8 2-[6-benzyloxy-3'-(tert-butoxycarbonylamino-methyl)-5-(4-chloro-1H-pyrrolo[3,2-c]pyridin-2-yl)-biphenyl-3-yl]-2-methyl-propionic acid 
• 909036-45-9 2-[3'-aminomethyl-5-(4-amino-1H-pyrrolo[3,2-c]pyridin-2-yl)-6-hydroxy-biphenyl-3-yl]-2-methyl-propionic acid 
• 909036-42-6 2-[6-benzyloxy-3'-(tert-butoxycarbonylamino-methyl)-5-ethynyl-biphenyl-3-yl]-2-methyl-propionic acid methyl ester 
• 909036-41-5 2-[6-benzyloxy-3'-(tert-butoxycarbonylamino-methyl)-5-formyl-biphenyl-3-yl]-2-methyl-propionic acid methyl ester 
• 909036-40-4 2-(4-benzyloxy-3-bromo-5-formyl-phenyl)-2-methyl-propionic acid methyl ester 
• 731015-45-5 methyl 2-(3-bromo-5-formyl-4-hydroxy-phenyl)-2-methyl-propionate 

Relevant academic research and scientific papers

COMPOUNDS AND METHODS

The present invention relates to novel retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORy.

Potent 4-amino-5-azaindole factor VIIa inhibitors

The 4-amino-5-azaindole as an amidino-benzimidazole replacement is described. A series of potent and selective analogs were discovered and showed desirable ex vivo efficacy as measured by PT.

FACTOR VIIA INHIBITOR

The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders

2-'5-(5-CARBAMIMIDOYL-1H-HETEROARYL)-6-HYDROXYBIPHENYL-3-YL!- CARBOXYLIC ACID DERIVATIVES AS FACTOR VIIA INHIBITORS

The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders. Processes for preparing these inhibitors are also disclosed.