N-(tert-butyl)-2-(2-chloro-4-fluorophenyl)-2-(5,5-dimethyl-3-oxo-5,6-dihydro-1H-cyclopenta[c]pyridin-2(3H)-yl)acetamide

Base Information

Chemical Name:N-(tert-butyl)-2-(2-chloro-4-fluorophenyl)-2-(5,5-dimethyl-3-oxo-5,6-dihydro-1H-cyclopenta[c]pyridin-2(3H)-yl)acetamide
CAS No.:1448150-36-4
Molecular Formula:C₂₂H₂₆ClFN₂O₂
Molecular Weight:404.912
Hs Code.:

Synonyms:N-(tert-butyl)-2-(2-chloro-4-fluorophenyl)-2-(5,5-dimethyl-3-oxo-5,6-dihydro-1H-cyclopenta[c]pyridin-2(3H)-yl)acetamide

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Chemical Property of N-(tert-butyl)-2-(2-chloro-4-fluorophenyl)-2-(5,5-dimethyl-3-oxo-5,6-dihydro-1H-cyclopenta[c]pyridin-2(3H)-yl)acetamide

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Technology Process of N-(tert-butyl)-2-(2-chloro-4-fluorophenyl)-2-(5,5-dimethyl-3-oxo-5,6-dihydro-1H-cyclopenta[c]pyridin-2(3H)-yl)acetamide

There total 2 articles about N-(tert-butyl)-2-(2-chloro-4-fluorophenyl)-2-(5,5-dimethyl-3-oxo-5,6-dihydro-1H-cyclopenta[c]pyridin-2(3H)-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1448150-16-0
N-(2-(tert-butylamino)-1-(2-chloro-4-fluorophenyl)-2-oxoethyl)-4,4-dimethyl-N-(prop-2-yn-1-yl)pent-2-ynamide

: 1448150-36-4
N-(tert-butyl)-2-(2-chloro-4-fluorophenyl)-2-(5,5-dimethyl-3-oxo-5,6-dihydro-1H-cyclopenta[c]pyridin-2(3H)-yl)acetamide

Guidance literature:: With chloro(1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene)gold(I); silver trifluoromethanesulfonate; In 1,2-dichloro-ethane; at 120 ℃; regioselective reaction; Inert atmosphere;
DOI:10.1039/c3cc43418d

Reference yield:

: 52418-50-5
4,4-dimethyl-2-pentynoic acid

: 119072-55-8,7188-38-7
tert-butylisonitrile

: 84194-36-5
2-chloro-4-fluorobenzaldehyde

: 1448150-36-4
N-(tert-butyl)-2-(2-chloro-4-fluorophenyl)-2-(5,5-dimethyl-3-oxo-5,6-dihydro-1H-cyclopenta[c]pyridin-2(3H)-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium sulfate / methanol / 20 °C / Inert atmosphere

2: chloro(1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene)gold(I); silver trifluoromethanesulfonate / 1,2-dichloro-ethane / 120 °C / Inert atmosphere

With chloro(1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene)gold(I); silver trifluoromethanesulfonate; sodium sulfate; In methanol; 1,2-dichloro-ethane; 1: |Ugi Condensation;
DOI:10.1039/c3cc43418d