Technology Process of (R)-(-)-4,6-dimethoxy-2-hydroxybenzoic acid (1-methyl-hept-7-enyl)ester
There total 5 articles about (R)-(-)-4,6-dimethoxy-2-hydroxybenzoic acid (1-methyl-hept-7-enyl)ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triphenylphosphine; diethylazodicarboxylate;
In
diethyl ether;
Ambient temperature;
DOI:10.1016/0040-4039(96)01590-0
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 80 percent / NaOMe / methanol / 12 h / 120 °C / 30400 Torr
2: 83 percent / EtOOC-N=N-COOEt; PPh3 / diethyl ether / 25 °C
With
sodium methylate; triphenylphosphine; diethylazodicarboxylate;
In
methanol; diethyl ether;
1: Kolbe-Schmitt reaction / 2: Esterification;
DOI:10.1016/S0040-4020(99)00302-6
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: Mg / tetrahydrofuran
1.2: 81 percent / CuCl(COD) / tetrahydrofuran / -78 - 25 °C
2.1: 83 percent / EtOOC-N=N-COOEt; PPh3 / diethyl ether / 25 °C
With
magnesium; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; diethyl ether;
1.1: Metallation / 1.2: Substitution / 2.1: Esterification;
DOI:10.1016/S0040-4020(99)00302-6
