3-{2-[4-benzyloxy-3-(4-phenylpiperidin-4-yl)phenyl]ethoxy}propionic acid trifluoroacetate

Base Information

Chemical Name:3-{2-[4-benzyloxy-3-(4-phenylpiperidin-4-yl)phenyl]ethoxy}propionic acid trifluoroacetate
CAS No.:1295644-38-0
Molecular Formula:C₂HF₃O₂*C₂₉H₃₃NO₄
Molecular Weight:573.609
Hs Code.:

Synonyms:3-{2-[4-benzyloxy-3-(4-phenylpiperidin-4-yl)phenyl]ethoxy}propionic acid trifluoroacetate

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Chemical Property of 3-{2-[4-benzyloxy-3-(4-phenylpiperidin-4-yl)phenyl]ethoxy}propionic acid trifluoroacetate

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Technology Process of 3-{2-[4-benzyloxy-3-(4-phenylpiperidin-4-yl)phenyl]ethoxy}propionic acid trifluoroacetate

There total 7 articles about 3-{2-[4-benzyloxy-3-(4-phenylpiperidin-4-yl)phenyl]ethoxy}propionic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1295644-36-8
4-{2-benzyloxy-5-[2-(2-tert-butoxycarbonylethoxy)ethyl]phenyl}-4-phenylpiperidine-1-carboxylic acid tert-butyl ester

: 76-05-1
trifluoroacetic acid

: 1295644-38-0
3-{2-[4-benzyloxy-3-(4-phenylpiperidin-4-yl)phenyl]ethoxy}propionic acid trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 40807-61-2
4-hydroxy-4-phenylpiperidin

: 1295644-38-0
3-{2-[4-benzyloxy-3-(4-phenylpiperidin-4-yl)phenyl]ethoxy}propionic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: trifluorormethanesulfonic acid / nitrobenzene / 0 - 20 °C

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 50 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / -5 °C / Inert atmosphere

4.2: Cooling

5.1: N-benzyl-trimethylammonium hydroxide / toluene; methanol

5.2: 0 - 20 °C

6.1: dichloromethane / 2 h / 20 °C

With lithium aluminium tetrahydride; trifluorormethanesulfonic acid; N-benzyl-trimethylammonium hydroxide; caesium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; nitrobenzene; N,N-dimethyl-formamide; toluene;

Reference yield:

: 14199-15-6
Methyl 4-hydroxyphenylacetate

: 1295644-38-0
3-{2-[4-benzyloxy-3-(4-phenylpiperidin-4-yl)phenyl]ethoxy}propionic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: trifluorormethanesulfonic acid / nitrobenzene / 0 - 20 °C

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 50 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / -5 °C / Inert atmosphere

4.2: Cooling

5.1: N-benzyl-trimethylammonium hydroxide / toluene; methanol

5.2: 0 - 20 °C

6.1: dichloromethane / 2 h / 20 °C

With lithium aluminium tetrahydride; trifluorormethanesulfonic acid; N-benzyl-trimethylammonium hydroxide; caesium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; nitrobenzene; N,N-dimethyl-formamide; toluene;