3-{2-[4-benzyloxy-3-(1-methyl-4-phenylpiperidin-4-yl)phenyl]ethoxy}propionic acid

Base Information

Chemical Name:3-{2-[4-benzyloxy-3-(1-methyl-4-phenylpiperidin-4-yl)phenyl]ethoxy}propionic acid
CAS No.:1295644-39-1
Molecular Formula:C₃₀H₃₅NO₄
Molecular Weight:473.612
Hs Code.:

Synonyms:3-{2-[4-benzyloxy-3-(1-methyl-4-phenylpiperidin-4-yl)phenyl]ethoxy}propionic acid

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Chemical Property of 3-{2-[4-benzyloxy-3-(1-methyl-4-phenylpiperidin-4-yl)phenyl]ethoxy}propionic acid

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Technology Process of 3-{2-[4-benzyloxy-3-(1-methyl-4-phenylpiperidin-4-yl)phenyl]ethoxy}propionic acid

There total 8 articles about 3-{2-[4-benzyloxy-3-(1-methyl-4-phenylpiperidin-4-yl)phenyl]ethoxy}propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1295644-38-0
3-{2-[4-benzyloxy-3-(4-phenylpiperidin-4-yl)phenyl]ethoxy}propionic acid trifluoroacetate

: 1295644-39-1
3-{2-[4-benzyloxy-3-(1-methyl-4-phenylpiperidin-4-yl)phenyl]ethoxy}propionic acid

Guidance literature:: formaldehyd; 3-{2-[4-benzyloxy-3-(4-phenylpiperidin-4-yl)phenyl]ethoxy}propionic acid trifluoroacetate; With water; In 1,2-dichloro-ethane; for 0.166667h;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; for 16h;

Reference yield:

: 40807-61-2
4-hydroxy-4-phenylpiperidin

: 1295644-39-1
3-{2-[4-benzyloxy-3-(1-methyl-4-phenylpiperidin-4-yl)phenyl]ethoxy}propionic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: trifluorormethanesulfonic acid / nitrobenzene / 0 - 20 °C

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 50 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / -5 °C / Inert atmosphere

4.2: Cooling

5.1: N-benzyl-trimethylammonium hydroxide / toluene; methanol

5.2: 0 - 20 °C

6.1: dichloromethane / 2 h / 20 °C

7.1: water / 1,2-dichloro-ethane / 0.17 h

7.2: 16 h

With lithium aluminium tetrahydride; trifluorormethanesulfonic acid; water; N-benzyl-trimethylammonium hydroxide; caesium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; nitrobenzene; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 14199-15-6
Methyl 4-hydroxyphenylacetate

: 1295644-39-1
3-{2-[4-benzyloxy-3-(1-methyl-4-phenylpiperidin-4-yl)phenyl]ethoxy}propionic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: trifluorormethanesulfonic acid / nitrobenzene / 0 - 20 °C

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 50 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / -5 °C / Inert atmosphere

4.2: Cooling

5.1: N-benzyl-trimethylammonium hydroxide / toluene; methanol

5.2: 0 - 20 °C

6.1: dichloromethane / 2 h / 20 °C

7.1: water / 1,2-dichloro-ethane / 0.17 h

7.2: 16 h

With lithium aluminium tetrahydride; trifluorormethanesulfonic acid; water; N-benzyl-trimethylammonium hydroxide; caesium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; nitrobenzene; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;