3-(3,4-dichlorophenyl)-N,N-diethyl-3-(pyrrolidin-1-yl)propan-1-amine hydrochloride

Base Information

Chemical Name:3-(3,4-dichlorophenyl)-N,N-diethyl-3-(pyrrolidin-1-yl)propan-1-amine hydrochloride
CAS No.:1346460-37-4
Molecular Formula:C₁₇H₂₆Cl₂N₂*ClH
Molecular Weight:365.774
Hs Code.:

Synonyms:3-(3,4-dichlorophenyl)-N,N-diethyl-3-(pyrrolidin-1-yl)propan-1-amine hydrochloride

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Chemical Property of 3-(3,4-dichlorophenyl)-N,N-diethyl-3-(pyrrolidin-1-yl)propan-1-amine hydrochloride

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Technology Process of 3-(3,4-dichlorophenyl)-N,N-diethyl-3-(pyrrolidin-1-yl)propan-1-amine hydrochloride

There total 5 articles about 3-(3,4-dichlorophenyl)-N,N-diethyl-3-(pyrrolidin-1-yl)propan-1-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.1%

: 123-75-1
pyrrolidine

: 1346461-00-4
C₁₃H₁₉Cl₂NO*ClH

: 1346460-37-4
3-(3,4-dichlorophenyl)-N,N-diethyl-3-(pyrrolidin-1-yl)propan-1-amine hydrochloride

Guidance literature:: C₁₃H₁₉Cl₂NO*ClH; With toluene-4-sulfonic acid; triethylamine; In acetonitrile; at 20 ℃; for 12h;

pyrrolidine; With potassium carbonate; In acetonitrile; at 20 ℃; for 8h;

With hydrogenchloride; In ethyl acetate;

Reference yield:

: 3-(3,4-dichlorophenyl)-N,N-diethyl-3-(pyrrolidin-1-yl)propan-1-amine

: 1346460-37-4
3-(3,4-dichlorophenyl)-N,N-diethyl-3-(pyrrolidin-1-yl)propan-1-amine hydrochloride

Guidance literature:: With hydrogenchloride; In ethanol; at 20 ℃; for 1h;
DOI:10.1016/j.ejmech.2014.08.045

Reference yield:

: 95-50-1
1,2-dichloro-benzene

: 1346460-37-4
3-(3,4-dichlorophenyl)-N,N-diethyl-3-(pyrrolidin-1-yl)propan-1-amine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: aluminum (III) chloride / 8 h / 70 °C

2.1: N-ethyl-N,N-diisopropylamine / ethanol / 12 h / 20 °C

3.1: sodium tetrahydroborate / methanol / 3 h / 20 °C

4.1: triethylamine; toluene-4-sulfonic acid / acetonitrile / 12 h / 20 °C

4.2: 8 h / 20 °C

With aluminum (III) chloride; sodium tetrahydroborate; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; acetonitrile;