C₂₁H₂₇NOSi

Base Information

• Chemical Name: C₂₁H₂₇NOSi
• CAS No.: 1359984-40-9
• Molecular Formula: C₂₁H₂₇NOSi
• Molecular Weight: 337.537
• Mol file: 1359984-40-9.mol

Synonyms:C₂₁H₂₇NOSi

Chemical Property of C₂₁H₂₇NOSi

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₇NOSi

There total 1 articles about C₂₁H₂₇NOSi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(R)-(+)-2-hydroxypentanenitrile (10021-63-3) + tert-butylchlorodiphenylsilane (58479-61-1) → C21H27NOSi (1359984-40-9)

Guidance literature:

With 1H-imidazole; dmap; for 12h;

DOI:10.1016/j.tetlet.2011.12.119

Reference yield: 82.0%

C21H27NOSi (1359984-40-9) → (R)-(+)-2-(tert-Butyldiphenylsilyloxy)pentanal

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; at -78 ℃;

DOI:10.1016/j.tetlet.2011.12.119

Reference yield:

C21H27NOSi (1359984-40-9) → C27H38O3Si (1359984-27-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: diisobutylaluminium hydride / dichloromethane / -78 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C

2.2: 0 °C

3.1: AD-mix β; methanesulfonamide; water / tert-butyl alcohol / 24 h / 20 °C

4.1: CSA

5.1: diisobutylaluminium hydride / dichloromethane / -78 °C

6.1: lithium hexamethyldisilazane / 1 h / 0 °C

With methanesulfonamide; AD-mix β; water; sodium hydride; diisobutylaluminium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; mineral oil; tert-butyl alcohol; 2.1: Horner-Wadsworth-Emmons olefination / 2.2: Horner-Wadsworth-Emmons olefination / 3.1: Sharpless dihydroxylation / 6.1: Wittig reaction;

DOI:10.1016/j.tetlet.2011.12.119

upstream raw materials:

(R)-(+)-2-hydroxypentanenitrile

tert-butylchlorodiphenylsilane

Downstream raw materials:

(2R,3S,4R)-ethyl 4-(tert-butyldiphenylsilyloxy)-2,3-dihydroxyheptanoate

C₂₈H₄₀O₅Si

C₂₆H₃₆O₄Si

C₂₇H₃₈O₃Si

Refernces