methyl 3-(5-acetoxy-1-(4-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)propanoate

Base Information

Chemical Name:methyl 3-(5-acetoxy-1-(4-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)propanoate
CAS No.:1415230-89-5
Molecular Formula:C₁₆H₁₇ClN₂O₄
Molecular Weight:336.775
Hs Code.:

Synonyms:methyl 3-(5-acetoxy-1-(4-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)propanoate

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Chemical Property of methyl 3-(5-acetoxy-1-(4-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)propanoate

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Technology Process of methyl 3-(5-acetoxy-1-(4-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)propanoate

There total 3 articles about methyl 3-(5-acetoxy-1-(4-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1412907-25-5
1-(4-chlorophenyl)-3-methyl-1H-pyrazol-5-yl acetate

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 1415230-89-5
methyl 3-(5-acetoxy-1-(4-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)propanoate

: 1415231-05-8
dimethyl 3,3'-(1-(4-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazole-4,4-diyl)dipropanoate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1016/j.tetlet.2012.09.096

Reference yield:

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 1415230-89-5
methyl 3-(5-acetoxy-1-(4-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)propanoate

: 1415231-05-8
dimethyl 3,3'-(1-(4-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazole-4,4-diyl)dipropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / ethanol / 24 h / 60 °C / Reflux

2: 12 h / 20 °C

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 24 h / 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In ethanol; dichloromethane; 3: |Michael Addition;
DOI:10.1016/j.tetlet.2012.09.096

Reference yield:

: 13024-90-3
1-(4-chlorophenyl)-3-methyl-2-pyrazolin-5-one

: 1415230-89-5
methyl 3-(5-acetoxy-1-(4-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)propanoate

: 1415231-05-8
dimethyl 3,3'-(1-(4-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazole-4,4-diyl)dipropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 12 h / 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 24 h / 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; 2: |Michael Addition;
DOI:10.1016/j.tetlet.2012.09.096