6-(5-chloropyrimidin-2-yl)-3-[4-(2-hydroxy-2-methyl-propoxy)-3-methoxy-phenyl]-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one

Base Information

Chemical Name:6-(5-chloropyrimidin-2-yl)-3-[4-(2-hydroxy-2-methyl-propoxy)-3-methoxy-phenyl]-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one
CAS No.:1221419-70-0
Molecular Formula:C₂₁H₂₀ClN₅O₄
Molecular Weight:441.874
Hs Code.:

Synonyms:6-(5-chloropyrimidin-2-yl)-3-[4-(2-hydroxy-2-methyl-propoxy)-3-methoxy-phenyl]-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one

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Chemical Property of 6-(5-chloropyrimidin-2-yl)-3-[4-(2-hydroxy-2-methyl-propoxy)-3-methoxy-phenyl]-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one

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Technology Process of 6-(5-chloropyrimidin-2-yl)-3-[4-(2-hydroxy-2-methyl-propoxy)-3-methoxy-phenyl]-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one

There total 2 articles about 6-(5-chloropyrimidin-2-yl)-3-[4-(2-hydroxy-2-methyl-propoxy)-3-methoxy-phenyl]-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124405-67-0
2-bromo-5-chloro-pyrimidine

: C₂₃H₃₀BN₃O₆

: 1221419-70-0
6-(5-chloropyrimidin-2-yl)-3-[4-(2-hydroxy-2-methyl-propoxy)-3-methoxy-phenyl]-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 1h; Microwave irradiation;
DOI:10.1016/j.bmcl.2015.09.018

Reference yield:

: 1221419-70-0
6-(5-chloropyrimidin-2-yl)-3-[4-(2-hydroxy-2-methyl-propoxy)-3-methoxy-phenyl]-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one

Guidance literature:

Reference yield: 77.0%

: 4530-20-5
BOC-glycine

: 79785-97-0
hydrazine hydrate

: 1221419-70-0
6-(5-chloropyrimidin-2-yl)-3-[4-(2-hydroxy-2-methyl-propoxy)-3-methoxy-phenyl]-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one

: 1221420-56-9
1-(4-(6-(5-chloropyrimidin-2-yl)-4-oxopyrrolo[1,2-f][1,2,4]triazin-3(4H)-yl)-2-methoxyphenoxy)-2-methylpropan-2-yl 2-(tert-butoxycarbonylamino)acetate

Guidance literature:: BOC-glycine; 6-(5-chloropyrimidin-2-yl)-3-[4-(2-hydroxy-2-methyl-propoxy)-3-methoxy-phenyl]-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one; With 4-pyrrolidin-1-ylpyridine; diisopropyl-carbodiimide; In dichloromethane; at 20 - 42 ℃;

hydrazine hydrate; In dichloromethane; at 20 ℃; for 1h;