3-(2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)phenyl)propan-1-ol

Base Information

• Chemical Name: 3-(2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)phenyl)propan-1-ol
• CAS No.: 1338380-61-2
• Molecular Formula: C₁₄H₁₉NO₂
• Molecular Weight: 233.31
• Mol file: 1338380-61-2.mol

Synonyms:3-(2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)phenyl)propan-1-ol

Chemical Property of 3-(2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)phenyl)propan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)phenyl)propan-1-ol

There total 1 articles about 3-(2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)phenyl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.7%

4,4-dimethyl-2-[2-(prop-2-enyl)]phenyl-2-oxazoline (133341-93-2) → 3-(2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)phenyl)propan-1-ol (1338380-61-2)

Guidance literature:

4,4-dimethyl-2-[2-(prop-2-enyl)]phenyl-2-oxazoline; With 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; at 0 - 20 ℃; for 4h;

With dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; water; at 60 ℃; for 2.5h;

DOI:10.1016/j.bmc.2011.07.057

Reference yield: 54.5%

methanol (67-56-1) + 3-(2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)phenyl)propan-1-ol (1338380-61-2) → 2-(3-Hydroxypropyl)benzoesaeure-methylester (106515-76-8)

Guidance literature:

With hydrogenchloride; for 30h; Reflux;

DOI:10.1016/j.bmc.2011.07.057

Reference yield:

3-(2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)phenyl)propan-1-ol (1338380-61-2) → C10H10ClNO3

Guidance literature:

Multi-step reaction with 5 steps

1: hydrogenchloride / 30 h / Reflux

2: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 0 °C

3: sodium nitrite / ethylene glycol; N,N-dimethyl-formamide / 4 h / 20 °C

4: hydrogenchloride; water; acetic acid / 14 h / Reflux

5: thionyl chloride / benzene / 2.5 h / Reflux

With hydrogenchloride; thionyl chloride; carbon tetrabromide; water; acetic acid; triphenylphosphine; sodium nitrite; In dichloromethane; ethylene glycol; N,N-dimethyl-formamide; benzene;

DOI:10.1016/j.bmc.2011.07.057

upstream raw materials:

4,4-dimethyl-2-[2-(prop-2-enyl)]phenyl-2-oxazoline

Downstream raw materials:

2-(3-Hydroxypropyl)benzoesaeure-methylester

methyl 2-(3-nitropropyl)benzoate

2-(3-nitropropyl)benzoic acid

(3,4-dimethoxyphenyl)(2-(3-nitropropyl)phenyl)methanone