6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-N-[(1R)-2-(methyloxy)-1-phenylethyl]-3-pyridazinamine

Base Information

Chemical Name:6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-N-[(1R)-2-(methyloxy)-1-phenylethyl]-3-pyridazinamine
CAS No.:1145786-23-7
Molecular Formula:C₂₄H₂₅N₅O₂
Molecular Weight:415.495
Hs Code.:

Synonyms:6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-N-[(1R)-2-(methyloxy)-1-phenylethyl]-3-pyridazinamine

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Chemical Property of 6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-N-[(1R)-2-(methyloxy)-1-phenylethyl]-3-pyridazinamine

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Technology Process of 6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-N-[(1R)-2-(methyloxy)-1-phenylethyl]-3-pyridazinamine

There total 6 articles about 6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-N-[(1R)-2-(methyloxy)-1-phenylethyl]-3-pyridazinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1145786-68-0
6-chloro-N-[(1R)-2-(methyloxy)-1-phenylethyl]-3-pyridazinamine

: 1145786-45-3
[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]boronic acid

: 1145786-44-2
4-methyl-1-[2-(methyloxy)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1H-imidazole

: 1145786-23-7
6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-N-[(1R)-2-(methyloxy)-1-phenylethyl]-3-pyridazinamine

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 80 ℃; for 6h;

Reference yield:

: 870838-56-5
1-(4-bromo-2-methoxyphenyl)-4-methyl-1H-imidazole

: 1145786-23-7
6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-N-[(1R)-2-(methyloxy)-1-phenylethyl]-3-pyridazinamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium; Triisopropyl borate

1.2: Reflux

2.1: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine / toluene / Reflux

With n-butyllithium; Triisopropyl borate; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; In toluene; 1.2: Suzuki coupling / 2.1: Buchwald reaction;
DOI:10.1016/j.bmcl.2011.04.143

Reference yield:

: 59557-91-4
4-bromo-2-methoxyaniline

: 1145786-23-7
6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-N-[(1R)-2-(methyloxy)-1-phenylethyl]-3-pyridazinamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid; potassium iodide; sodium nitrite

2.1: 8-quinolinol; copper(l) iodide; caesium carbonate

3.1: n-butyllithium; Triisopropyl borate

3.2: Reflux

4.1: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine / toluene / Reflux

With copper(l) iodide; 8-quinolinol; n-butyllithium; Triisopropyl borate; palladium diacetate; caesium carbonate; toluene-4-sulfonic acid; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; potassium iodide; sodium nitrite; In toluene; 3.2: Suzuki coupling / 4.1: Buchwald reaction;
DOI:10.1016/j.bmcl.2011.04.143