di-tert-butyl N-{α-tert-butyl-N-[4-(N-benzyloxycarbonyl-N-methyl)aminobenzoyl]-L-glutamyl-γ}-L-glutamate

Base Information

Chemical Name:di-tert-butyl N-{α-tert-butyl-N-[4-(N-benzyloxycarbonyl-N-methyl)aminobenzoyl]-L-glutamyl-γ}-L-glutamate
CAS No.:875667-99-5
Molecular Formula:C₃₈H₅₃N₃O₁₀
Molecular Weight:711.853
Hs Code.:

Synonyms:di-tert-butyl N-{α-tert-butyl-N-[4-(N-benzyloxycarbonyl-N-methyl)aminobenzoyl]-L-glutamyl-γ}-L-glutamate

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Chemical Property of di-tert-butyl N-{α-tert-butyl-N-[4-(N-benzyloxycarbonyl-N-methyl)aminobenzoyl]-L-glutamyl-γ}-L-glutamate

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Technology Process of di-tert-butyl N-{α-tert-butyl-N-[4-(N-benzyloxycarbonyl-N-methyl)aminobenzoyl]-L-glutamyl-γ}-L-glutamate

There total 5 articles about di-tert-butyl N-{α-tert-butyl-N-[4-(N-benzyloxycarbonyl-N-methyl)aminobenzoyl]-L-glutamyl-γ}-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-azidocarbonyl-2-[4-(benzyloxycarbonyl-methyl-amino)-benzoylamino]-butyric acid tert-butyl ester

: 16874-06-9
di-tert-butyl L-glutamate

: 875667-99-5
di-tert-butyl N-{α-tert-butyl-N-[4-(N-benzyloxycarbonyl-N-methyl)aminobenzoyl]-L-glutamyl-γ}-L-glutamate

Guidance literature:: With 1,1,3,3-tetramethylguanidine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm050871p

Reference yield:

: 875667-97-3
(4-azidocarbonyl-phenyl)-methyl-carbamic acid benzyl ester

: 875667-99-5
di-tert-butyl N-{α-tert-butyl-N-[4-(N-benzyloxycarbonyl-N-methyl)aminobenzoyl]-L-glutamyl-γ}-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: 146 mg / tetramethylguanidine / dimethylformamide / 48 h / 20 °C

2: (PhO)2P(O)N₃; Et₃N / dimethylformamide / 2.5 h

3: 628 mg / tetramethylguanidine / dimethylformamide / 20 °C

With 1,1,3,3-tetramethylguanidine; diphenyl phosphoryl azide; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm050871p

Reference yield:

: 45120-30-7
L-glutamic acid α-tert-butyl ester

: 875667-99-5
di-tert-butyl N-{α-tert-butyl-N-[4-(N-benzyloxycarbonyl-N-methyl)aminobenzoyl]-L-glutamyl-γ}-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: 146 mg / tetramethylguanidine / dimethylformamide / 48 h / 20 °C

2: (PhO)2P(O)N₃; Et₃N / dimethylformamide / 2.5 h

3: 628 mg / tetramethylguanidine / dimethylformamide / 20 °C

With 1,1,3,3-tetramethylguanidine; diphenyl phosphoryl azide; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm050871p