ABT-288

Base Information

Chemical Name:ABT-288
CAS No.:948845-91-8
Molecular Formula:C₂₃H₂₄N₄O
Molecular Weight:372.47
Hs Code.:

Synonyms:ABT-288

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Chemical Property of ABT-288

Chemical Property:

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Technology Process of ABT-288

There total 8 articles about ABT-288 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.9%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 948846-70-6
2-{4'-[(3aR,6aR)-hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl]-1,1'-biphenyl-4-yl}pyridazin-3(2H)-one

: 948845-91-8
ABT-288

Guidance literature:: With sodium tris(acetoxy)borohydride; In ISOPROPYLAMIDE; water; at 20 - 30 ℃; for 0.5h; Product distribution / selectivity;

Reference yield:

: 504-30-3
2H-Pyridazin-3-one

: (3aR,6aR)-1-(4'-bromo-biphenyl-4-yl)-5-methyl-octahydropyrrolo[3,4-b]pyrrole

: 948845-91-8
ABT-288

Guidance literature:: With copper; potassium carbonate; In quinoline; at 150 ℃; for 48h;

Reference yield:

: 132414-79-0,894854-14-9
ethyl hexahydro-1H-pyrrolo[2,3-c]pyrrole-5-carboxylate

: 948845-91-8
ABT-288

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol / 2 h / 55 - 65 °C

2.1: potassium hydroxide; water / dichloromethane / 2.75 h / 0 °C

3.1: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrahydrofuran / 20 h / 70 °C

4.1: hydrogenchloride; water; acetic acid / 16 h / 100 °C

4.2: 0 °C / pH ~ 10

5.1: sodium tris(acetoxy)borohydride / N,N-dimethyl acetamide; water / 0.5 h / 20 - 30 °C

With hydrogenchloride; potassium hydroxide; water; sodium tris(acetoxy)borohydride; caesium carbonate; acetic acid; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide; water;