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504-30-3 Usage

Uses

Pyridazin-3(2H)-one can be used for anti-inflammatory and analgesic drug discovery.

Check Digit Verification of cas no

The CAS Registry Mumber 504-30-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,0 and 4 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 504-30:
(5*5)+(4*0)+(3*4)+(2*3)+(1*0)=43
43 % 10 = 3
So 504-30-3 is a valid CAS Registry Number.
InChI:InChI=1/C4H4N2O/c7-4-2-1-3-5-6-4/h1-3H,(H,6,7)

504-30-3 Well-known Company Product Price

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  • Detail
  • Alfa Aesar

  • (H55334)  3(2H)-Pyridazinone, 96%   

  • 504-30-3

  • 250mg

  • 593.0CNY

  • Detail
  • Alfa Aesar

  • (H55334)  3(2H)-Pyridazinone, 96%   

  • 504-30-3

  • 1g

  • 1660.0CNY

  • Detail
  • Alfa Aesar

  • (H55334)  3(2H)-Pyridazinone, 96%   

  • 504-30-3

  • 5g

  • 4307.0CNY

  • Detail
  • Aldrich

  • (82685)  3(2H)-Pyridazinone  ≥97.0% (GC)

  • 504-30-3

  • 82685-1G

  • 402.48CNY

  • Detail
  • Aldrich

  • (82685)  3(2H)-Pyridazinone  ≥97.0% (GC)

  • 504-30-3

  • 82685-5G

  • 7,891.65CNY

  • Detail

504-30-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 3(2H)-Pyridazinone

1.2 Other means of identification

Product number -
Other names 3-Hydroxypyridazine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:504-30-3 SDS

504-30-3Synthetic route

3-Phenyl-7aH-1-oxa-2,3a,4-triaza-indene
178047-61-5

3-Phenyl-7aH-1-oxa-2,3a,4-triaza-indene

2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

Conditions
ConditionsYield
With air In benzene Ambient temperature; Irradiation;90%
mucochloric acid
57697-64-0

mucochloric acid

2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

Conditions
ConditionsYield
Stage #1: mucochloric acid With tert-butylhydrazine In water; toluene at 23℃; for 2.8h;
Stage #2: With tetrabutylammomium bromide; titanium(IV) oxide In water; toluene at 20℃; for 4.6h; Temperature;
88.9%
N'-acryloyl-N-allyl-4-methylbenzenesulfonohydrazide
1173165-19-9

N'-acryloyl-N-allyl-4-methylbenzenesulfonohydrazide

2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

Conditions
ConditionsYield
With Hoveyda-Grubbs catalyst second generation In dichloromethane at 40℃; for 36h; Sealed tube; Inert atmosphere;87%
5-(1,2-diaza-1-t-butylbutadien-4-ylidene)-2,2-dimethyl-1,3-dioxan-4,6-dione
83297-14-7

5-(1,2-diaza-1-t-butylbutadien-4-ylidene)-2,2-dimethyl-1,3-dioxan-4,6-dione

2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

Conditions
ConditionsYield
at 750℃; under 0.01 - 0.1 Torr; for 1.5h;63%
6-chloro-2H-pyridazin-3-one
19064-67-6

6-chloro-2H-pyridazin-3-one

2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen; potassium carbonate In ethyl acetate under 1551.49 Torr; for 3h;55%
piperidine
110-89-4

piperidine

diethyl ether
60-29-7

diethyl ether

epichlorohydrin
106-89-8

epichlorohydrin

6-(3-allyl-4-hydroxy-phenyl)-4,5-dihydro-2H-pyridazin-3-one
56872-17-4

6-(3-allyl-4-hydroxy-phenyl)-4,5-dihydro-2H-pyridazin-3-one

A

2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

B

6-(3-allyl-4-oxiranylmethoxy-phenyl)-4,5-dihydro-2H-pyridazin-3-one
56872-18-5

6-(3-allyl-4-oxiranylmethoxy-phenyl)-4,5-dihydro-2H-pyridazin-3-one

Conditions
ConditionsYield
With sodium hydroxide In dichloromethaneA 47%
B n/a
1,2-diazine
289-80-5

1,2-diazine

benzonitrile oxide
873-67-6

benzonitrile oxide

A

2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

B

6a,9a,9b-trihydro-3,9-diphenylisoxazolo<4,5-d><1,2,4>oxadiazolo<4,5-b>pyridazine

6a,9a,9b-trihydro-3,9-diphenylisoxazolo<4,5-d><1,2,4>oxadiazolo<4,5-b>pyridazine

Conditions
ConditionsYield
In benzene for 3h; Heating;A 3%
B 29%
1,2-diazine
289-80-5

1,2-diazine

A

2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

B

6a,9a,9b-trihydro-3,9-diphenylisoxazolo<4,5-d><1,2,4>oxadiazolo<4,5-b>pyridazine

6a,9a,9b-trihydro-3,9-diphenylisoxazolo<4,5-d><1,2,4>oxadiazolo<4,5-b>pyridazine

Conditions
ConditionsYield
With benzonitrile oxide In benzene for 3h; Heating;A 3%
B 29%
3-oxo-2,3,4,5-tetrahydropyridazine
61468-81-3

3-oxo-2,3,4,5-tetrahydropyridazine

2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

Conditions
ConditionsYield
With chloroform; bromine
4,5-dichloro-2H-pyridazin-3-one
932-22-9

4,5-dichloro-2H-pyridazin-3-one

2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

Conditions
ConditionsYield
With sodium hydroxide; palladium on activated charcoal Hydrogenation;
4,5-dibromo-3(2H)pyridazinone
5788-58-9

4,5-dibromo-3(2H)pyridazinone

2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

Conditions
ConditionsYield
With sodium hydroxide; palladium on activated charcoal Hydrogenation;
6-oxo-1,6-dihydro-pyridazine-4-carboxylic acid
867130-58-3

6-oxo-1,6-dihydro-pyridazine-4-carboxylic acid

2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

Conditions
ConditionsYield
With copper
3-oxo-2,3-dihydro-pyridazine-4-carboxylic acid
54404-06-7

3-oxo-2,3-dihydro-pyridazine-4-carboxylic acid

2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

6-oxo-1,6-dihydro-pyridazine-3,4-dicarboxylic acid
867130-51-6

6-oxo-1,6-dihydro-pyridazine-3,4-dicarboxylic acid

2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

Conditions
ConditionsYield
With copper
3-(ethyloxy)pyridazine
62567-44-6

3-(ethyloxy)pyridazine

2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

Conditions
ConditionsYield
at 376.8℃; Rate constant; Thermodynamic data; further temperatures;
phosgene
75-44-5

phosgene

5-[3-(cyclopentyloxy)-4-methoxyphenyl]-1-methyl-3-pyrazolidinone
145743-48-2

5-[3-(cyclopentyloxy)-4-methoxyphenyl]-1-methyl-3-pyrazolidinone

A

2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

B

3-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-methyl-5-oxo-N-(3-pyridinylmethyl)-1-pyrazolidine carboxamide
145743-63-1

3-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-methyl-5-oxo-N-(3-pyridinylmethyl)-1-pyrazolidine carboxamide

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran; methanol; ethyl acetate; toluene
allyl bromide
106-95-6

allyl bromide

6-(3-hydroxyphenyl)-4,5-dihydro-3(2H)-pyridazinone
39499-64-4

6-(3-hydroxyphenyl)-4,5-dihydro-3(2H)-pyridazinone

A

2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

B

6-(3-allyloxy-phenyl)-4,5-dihydro-2H-pyridazin-3-one
56872-13-0

6-(3-allyloxy-phenyl)-4,5-dihydro-2H-pyridazin-3-one

Conditions
ConditionsYield
With potassium carbonate In acetone
propyl bromide
106-94-5

propyl bromide

6-(4-hydroxyphenyl)-4,5-dihydro-3(2H)-pyridazinone
39560-33-3

6-(4-hydroxyphenyl)-4,5-dihydro-3(2H)-pyridazinone

2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

Conditions
ConditionsYield
In sodium hydroxide; ethanol
C11H12N2O3S

C11H12N2O3S

2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 20℃;
2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

N,N-dimethyl-formamide dimethyl acetal
4637-24-5

N,N-dimethyl-formamide dimethyl acetal

2-methylpyridazin-3(2H)-one
22687-56-5

2-methylpyridazin-3(2H)-one

Conditions
ConditionsYield
In N,N-dimethyl-formamide Heating;96%
2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

4-bromoethylbutanoate
2969-81-5

4-bromoethylbutanoate

ethyl 4-[pyridazin-3(2H)-one-2-yl]-butyrate
346407-39-4

ethyl 4-[pyridazin-3(2H)-one-2-yl]-butyrate

Conditions
ConditionsYield
With potassium carbonate In acetone for 24h; Heating;95%
2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

4-iodobenzonitrile
3058-39-7

4-iodobenzonitrile

4-(6-oxo-6H-pyridazin-1-yl)-benzonitrile

4-(6-oxo-6H-pyridazin-1-yl)-benzonitrile

Conditions
ConditionsYield
With copper(II) 7-n-propyl-8-hydroxyquinolinate; potassium carbonate In N,N-dimethyl-formamide at 100℃; for 20h;94%
2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

6-Bromo-2-methyl-quinoline
877-42-9

6-Bromo-2-methyl-quinoline

2-(2-methyl-quinolin-6-yl)-2H-pyridazin-3-one

2-(2-methyl-quinolin-6-yl)-2H-pyridazin-3-one

Conditions
ConditionsYield
With copper(II) 7-n-propyl-8-hydroxyquinolinate; potassium carbonate In N,N-dimethyl-formamide at 140℃; for 20h;90%
2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

acrylonitrile
107-13-1

acrylonitrile

3-(3-oxo-2-pyridazinyl)propionitrile
73535-74-7

3-(3-oxo-2-pyridazinyl)propionitrile

Conditions
ConditionsYield
With potassium hydroxide; tetrabutylammomium bromide In benzene for 5h; Ambient temperature;89%
With N-benzyl-trimethylammonium hydroxide In ethanol for 8h; Heating;
2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

iodobenzene
591-50-4

iodobenzene

2-phenyl-2H-pyridazin-3-one
14135-63-8

2-phenyl-2H-pyridazin-3-one

Conditions
ConditionsYield
With caesium carbonate; hydroxybenzaldoxime; copper(I) oxide In acetonitrile at 82℃; for 100h;89%
2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

1-{[(1S,2S)-2-(4-bromophenyl)cyclopropyl]methyl}-(2S)-2-methylpyrrolidine
1000305-04-3

1-{[(1S,2S)-2-(4-bromophenyl)cyclopropyl]methyl}-(2S)-2-methylpyrrolidine

2-[4-((1S,2S)-2-{[(2S)-2-methylpyrrolidin-1-yl]methyl}cyclopropyl)phenyl]pyridazin-3(2H)-one

2-[4-((1S,2S)-2-{[(2S)-2-methylpyrrolidin-1-yl]methyl}cyclopropyl)phenyl]pyridazin-3(2H)-one

Conditions
ConditionsYield
With pyridine; potassium carbonate; copper(l) iodide; N,N`-dimethylethylenediamine In ethyl acetate at 115℃; Inert atmosphere;86%
With pyridine; copper(l) iodide; N,N`-dimethylethylenediamine at 135℃; for 16h;
With pyridine; copper(l) iodide; N,N`-dimethylethylenediamine at 135℃; for 16h; Inert atmosphere; Sealed tube;
2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

1-bromo-4-methoxy-benzene
104-92-7

1-bromo-4-methoxy-benzene

2-(4-methoxy-phenyl)-2H-pyridazin-3-one

2-(4-methoxy-phenyl)-2H-pyridazin-3-one

Conditions
ConditionsYield
With copper(II) 7-n-propyl-8-hydroxyquinolinate; potassium carbonate In N,N-dimethyl-formamide at 140℃; for 20h;85%
2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

dimethyl acetylenedicarboxylate
762-42-5

dimethyl acetylenedicarboxylate

dimethyl 2-(6-oxopyridazin-1(6H)-yl)fumarate
1274944-76-1

dimethyl 2-(6-oxopyridazin-1(6H)-yl)fumarate

Conditions
ConditionsYield
With triphenyl-arsane In acetone at -5℃; for 5.16667h; diastereospecific reaction;85%
With pyridine In dichloromethane at 20℃; for 24h; stereoselective reaction;80%
With triphenyl-arsane In methanol at 28℃; Catalytic behavior; Kinetics; Mechanism; Temperature; Reagent/catalyst; Concentration; diastereoselective reaction;
2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

6-bromo-2-(3,3-dimethoxycyclobutyl)benzothiazole
1416049-94-9

6-bromo-2-(3,3-dimethoxycyclobutyl)benzothiazole

2-(2-(3,3-dimethoxycyclobutyl)benzothiazol-6-yl)-pyridazin-3(2H)-one
1416049-95-0

2-(2-(3,3-dimethoxycyclobutyl)benzothiazol-6-yl)-pyridazin-3(2H)-one

Conditions
ConditionsYield
With pyridine; potassium carbonate; copper(l) chloride; N,N`-dimethylethylenediamine at 100℃; for 16.5h; Solvent; Reagent/catalyst; Inert atmosphere;84%
2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

ethyl acrylate
140-88-5

ethyl acrylate

ethyl 3-[pyridazin-3(2H)-one-2-yl]-propionate
73535-75-8

ethyl 3-[pyridazin-3(2H)-one-2-yl]-propionate

Conditions
ConditionsYield
In ethanol83%
bis(4-tert-butylphenyl)iodonium trifluoromethanesulfonate
84563-54-2

bis(4-tert-butylphenyl)iodonium trifluoromethanesulfonate

2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

2-(4-(tert-butyl)phenyl)pyridazin-3(2H)-one

2-(4-(tert-butyl)phenyl)pyridazin-3(2H)-one

Conditions
ConditionsYield
With triethylamine; copper(l) chloride In toluene at 20℃; for 1h; Inert atmosphere;82%
2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

ethyl (3aR,6aR)-1-(4'-bromo-1,1'-biphenyl-4-yl)hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate
948846-68-2

ethyl (3aR,6aR)-1-(4'-bromo-1,1'-biphenyl-4-yl)hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate

ethyl (3aR,6aR)-1-[4'-(6-oxopyridazin-1(6H)-yl)-1,1'-biphenyl-4-yl]hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate
948846-69-3

ethyl (3aR,6aR)-1-[4'-(6-oxopyridazin-1(6H)-yl)-1,1'-biphenyl-4-yl]hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate

Conditions
ConditionsYield
With potassium carbonate; copper(l) iodide; 8-quinolinol In N,N-dimethyl-formamide at 17 - 140℃; for 18h;81.9%
With copper(l) iodide; 8-quinolinol; potassium carbonate In N,N-dimethyl-formamide at 17 - 140℃; for 18h; Product distribution / selectivity;81.9%
2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

3-iodobenzonitrile
69113-59-3

3-iodobenzonitrile

3-(6-oxo-6H-pyridazin-1-yl)-benzonitrile

3-(6-oxo-6H-pyridazin-1-yl)-benzonitrile

Conditions
ConditionsYield
With copper(II) 7-n-propyl-8-hydroxyquinolinate; potassium carbonate In N,N-dimethyl-formamide at 100℃; for 20h;80%
2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

3,5-dimethylphenyl iodide
22445-41-6

3,5-dimethylphenyl iodide

2-(3,5-dimethyl-phenyl)-2H-pyridazin-3-one

2-(3,5-dimethyl-phenyl)-2H-pyridazin-3-one

Conditions
ConditionsYield
With copper(II) 7-n-propyl-8-hydroxyquinolinate; potassium carbonate In N,N-dimethyl-formamide at 100℃; for 20h;80%
2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

(6S,7R)-tert-butyl 7-(4-chloro-3-fluorophenyl)-6-((methylsulfonyloxy)methyl)-1,4-oxazepane-4-carboxylate
1372187-07-9

(6S,7R)-tert-butyl 7-(4-chloro-3-fluorophenyl)-6-((methylsulfonyloxy)methyl)-1,4-oxazepane-4-carboxylate

(6S,7R)-tert-butyl 7-(4-chloro-3-fluorophenyl)-6-((6-oxopyridazin-1(6H)-yl)methyl)-1,4-oxazepane-4-carboxylate

(6S,7R)-tert-butyl 7-(4-chloro-3-fluorophenyl)-6-((6-oxopyridazin-1(6H)-yl)methyl)-1,4-oxazepane-4-carboxylate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 4h;78%
2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

2-phenyl-1,3,4-oxadiazole
825-56-9

2-phenyl-1,3,4-oxadiazole

3-(5-phenyl-1,3,4-oxadiazol-2-yl)pyridazine
1366397-77-4

3-(5-phenyl-1,3,4-oxadiazol-2-yl)pyridazine

Conditions
ConditionsYield
Stage #1: 2H-Pyridazin-3-one With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate In 1,4-dioxane at 100℃; for 0.5h; Inert atmosphere; Sealed vessel; Microwave irradiation;
Stage #2: 2-phenyl-1,3,4-oxadiazole With copper(l) iodide; palladium diacetate; potassium carbonate; triphenylphosphine In 1,4-dioxane; 2,4-dichlorophenoxyacetic acid dimethylamine at 120℃; for 0.666667h; Inert atmosphere; Microwave irradiation; Sealed vessel;
75%
2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

trans-6-bromo-2-{3-[(2R)-2-methylpyrrolidin-1-yl]cyclobutyl}-1,3-benzothiazole

trans-6-bromo-2-{3-[(2R)-2-methylpyrrolidin-1-yl]cyclobutyl}-1,3-benzothiazole

trans-2-(2-{3-[(2R)-2-methylpyrrolidin-1-yl]cyclobutyl}-1,3-benzothiazol-6-yl)pyridazin-3(2H)-one

trans-2-(2-{3-[(2R)-2-methylpyrrolidin-1-yl]cyclobutyl}-1,3-benzothiazol-6-yl)pyridazin-3(2H)-one

Conditions
ConditionsYield
With pyridine; potassium carbonate; copper Heating / reflux;74%
2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

3-chloropyridazine
1120-95-2

3-chloropyridazine

Conditions
ConditionsYield
With trichlorophosphate at 60℃; for 1.5h;73%
With trichlorophosphate63%
Stage #1: 2H-Pyridazin-3-one With trichlorophosphate at 85℃; for 4.5h;
Stage #2: With sodium hydroxide In water at 0℃; pH=> 10;
46%
2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

1-bromo-butane
109-65-9

1-bromo-butane

2-Butyl-2H-pyridazin-3-one
79235-20-4

2-Butyl-2H-pyridazin-3-one

Conditions
ConditionsYield
With potassium hydroxide; tetrabutylammomium bromide In benzene for 5h; Ambient temperature;73%
2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

3,3'-bipyridazine
10198-96-6

3,3'-bipyridazine

Conditions
ConditionsYield
Stage #1: 2H-Pyridazin-3-one With triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate In 1,4-dioxane at 100℃; for 0.5h; Inert atmosphere; Sealed vessel; Microwave irradiation;
Stage #2: With copper(l) iodide; palladium diacetate; potassium carbonate; triphenylphosphine In 1,4-dioxane; 2,4-dichlorophenoxyacetic acid dimethylamine at 120℃; for 0.666667h; Inert atmosphere; Microwave irradiation; Sealed vessel;
71%
2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

benzoxazole
273-53-0

benzoxazole

2-(pyridazin-3-yl)benzo[d]oxazole
1366397-81-0

2-(pyridazin-3-yl)benzo[d]oxazole

Conditions
ConditionsYield
Stage #1: 2H-Pyridazin-3-one With triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate In 1,4-dioxane at 100℃; for 0.5h; Inert atmosphere; Sealed vessel; Microwave irradiation;
Stage #2: benzoxazole With copper(l) iodide; palladium diacetate; potassium carbonate; triphenylphosphine In 1,4-dioxane; 2,4-dichlorophenoxyacetic acid dimethylamine at 120℃; for 0.666667h; Inert atmosphere; Microwave irradiation; Sealed vessel;
71%
oxirane
75-21-8

oxirane

2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

2-(2-Hydroxyethyl)-3-pyridazone
74316-72-6

2-(2-Hydroxyethyl)-3-pyridazone

Conditions
ConditionsYield
With sodium methylate In methanol; N,N-dimethyl-formamide at 90℃; for 4h;70%
2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

4-chlorobutyl bromide
6940-78-9

4-chlorobutyl bromide

2-(4-chlorobutyl)-pyridazin-3(2H)-one

2-(4-chlorobutyl)-pyridazin-3(2H)-one

Conditions
ConditionsYield
With potassium carbonate In acetone Alkylation; Heating;70%
2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

Ethyl 3-bromopropionate
539-74-2

Ethyl 3-bromopropionate

ethyl 3-[pyridazin-3(2H)-one-2-yl]-propionate
73535-75-8

ethyl 3-[pyridazin-3(2H)-one-2-yl]-propionate

Conditions
ConditionsYield
With potassium carbonate In acetone for 24h; Heating;70%
2H-Pyridazin-3-one
504-30-3

2H-Pyridazin-3-one

2-bromo-6-iodo-naphthalene
389806-32-0

2-bromo-6-iodo-naphthalene

2-(6-bromo-naphthalen-2-yl)-2H-pyridazin-3-one

2-(6-bromo-naphthalen-2-yl)-2H-pyridazin-3-one

Conditions
ConditionsYield
With copper(II) 7-n-propyl-8-hydroxyquinolinate; potassium carbonate In N,N-dimethyl-formamide at 100℃; for 20h;70%

504-30-3Relevant articles and documents

Infrared matrix isolation and ab initio studies of 3(2H)-pyridazinone and photoproduced 3-hydroxypyridazine

Lapinski, Leszek,Fulara, Jan,Czerminski, Ryszard,Nowak, Maciej J.

, p. 1087 - 1096 (1990)

The infrared spectra of 3(2H)-pyridazinone and its rare tautomeric form, 3-hydroxypyridazine, isolated in an argon matrix are reported and discussed.Only the first tautomer was observed after deposition of the matrix.The second form was photochemically pr

Synthetic method of pyridazinone

-

Paragraph 0022-0031, (2021/03/30)

The invention relates to a new process for synthesizing pyridazinone, which is characterized in that C-TiO2 solid acid with a core-shell structure is used as a catalyst to replace traditional glacialacetic acid, tetramethyl ammonium bromide serves as a phase transfer catalyst, tert-butylhydrazine and furochloric acid are adopted to synthesize pyridazinone under certain conditions, the reaction efficiency is improved by adding the catalyst, and alkali washing and water washing processes are omitted, so that the yield and the quality of the product are improved, and the generation of three wastes is greatly reduced.

Synthesis of substituted pyridines and pyridazines via ring closing metathesis

Donohoe, Timothy J.,Fishlock, Lisa P.,Basutto, Jose A.,Bower, John F.,Procopiou, Panayiotis A.,Thompson, Amber L.

supporting information; experimental part, p. 3008 - 3010 (2009/12/01)

RCM can be used to make aromatic heterocycles, namely pyridines and, for the first time, pyridazines; the key step after RCM involves elimination of sulfinate to provide the aromatic system. The Royal Society of Chemistry 2009.

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