2-(2-benzyl-2H-tetrazol-5-yl)-1-phenylethanone

Base Information

• Chemical Name: 2-(2-benzyl-2H-tetrazol-5-yl)-1-phenylethanone
• CAS No.: 1446135-17-6
• Molecular Formula: C₁₆H₁₄N₄O
• Molecular Weight: 278.313
• Mol file: 1446135-17-6.mol

Synonyms:2-(2-benzyl-2H-tetrazol-5-yl)-1-phenylethanone

Chemical Property of 2-(2-benzyl-2H-tetrazol-5-yl)-1-phenylethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-benzyl-2H-tetrazol-5-yl)-1-phenylethanone

There total 1 articles about 2-(2-benzyl-2H-tetrazol-5-yl)-1-phenylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl bromide (100-39-0) + 1-phenyl-2-(1H-tetrazol-5-yl)ethanone (355116-17-5) → 2-(2-benzyl-2H-tetrazol-5-yl)-1-phenylethanone (1446135-17-6) + 2-(1-benzyl-1H-tetrazol-5-yl)-1-phenylethanone (116991-75-4)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 40 ℃; for 18h; Overall yield = 71 %; Overall yield = 1.98 g; regioselective reaction;

DOI:10.1021/jo4006552

Reference yield: 89.0%

2-(2-benzyl-2H-tetrazol-5-yl)-1-phenylethanone (1446135-17-6) → 2-(2-benzyl-2H-tetrazol-5-yl)-1-phenylethanone oxime (1446135-29-0)

Guidance literature:

With pyridine; hydroxylamine hydrochloride; In ethanol; for 3h; Reflux;

DOI:10.1021/jo4006552

Reference yield:

2-(2-benzyl-2H-tetrazol-5-yl)-1-phenylethanone (1446135-17-6) → 2-(2-benzyl-2H-tetrazol-5-yl)-3-phenyl-2H-azirine (1446135-39-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; pyridine / ethanol / 3 h / Reflux

2: p-toluenesulfonyl chloride; triethylamine / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

With pyridine; hydroxylamine hydrochloride; triethylamine; p-toluenesulfonyl chloride; In ethanol; dichloromethane; 2: |Neber Rearrangement;

DOI:10.1021/jo4006552

upstream raw materials:

benzyl bromide

1-phenyl-2-(1H-tetrazol-5-yl)ethanone

Downstream raw materials:

2-(2-benzyl-2H-tetrazol-5-yl)-1-phenylethanone oxime

2-(2-benzyl-2H-tetrazol-5-yl)-3-phenyl-2H-azirine