7-hydroxy-5-methoxy-2-benzofuran-1(3H)-one

Base Information

• Chemical Name: 7-hydroxy-5-methoxy-2-benzofuran-1(3H)-one
• CAS No.: 24953-77-3
• Molecular Formula: C₉H₈O₄
• Molecular Weight: 180.16
• Mol file: 24953-77-3.mol

Synonyms:Phthalide, 7-hydroxy-5-methoxy- (6CI,7CI,8CI);5-Methoxy-7-hydroxyphthalide; 7-Hydroxy-5-methoxyphthalide

Chemical Property of 7-hydroxy-5-methoxy-2-benzofuran-1(3H)-one

Chemical Property:

• Vapor Pressure: 5.69E-09mmHg at 25°C
• Boiling Point: 457°Cat760mmHg
• Flash Point: 194.6°C
• Density: 1.402g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-hydroxy-5-methoxy-2-benzofuran-1(3H)-one

There total 20 articles about 7-hydroxy-5-methoxy-2-benzofuran-1(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-(chloromethyl)-4,6-dimethoxy-benzaldehyde (166322-67-4) → 7-hydroxy-5-methoxyisobenzofuran-1(3H)-one (24953-77-3)

Guidance literature:

2-(chloromethyl)-4,6-dimethoxy-benzaldehyde; With boron trichloride; In dichloromethane; at 0 - 20 ℃; for 7h; Inert atmosphere;

With sodium chlorite; sodium dihydrogenphosphate; In tetrahydrofuran; water; tert-butyl alcohol; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/acs.joc.8b00802

Reference yield: 76.0%

5,7-dimethoxyphthalide (3465-69-8) → 7-hydroxy-5-methoxyisobenzofuran-1(3H)-one (24953-77-3)

Guidance literature:

With aluminium trichloride; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield: 50.0%

7-hydroxy-5-methoxyphthalide 7-O-β-D-glucopyranosyl-(1->6)-β-D-glucopyranoside (1190977-11-7) → 7-hydroxy-5-methoxyisobenzofuran-1(3H)-one (24953-77-3)

Guidance literature:

With water; cellulase; at 37 ℃; for 96h; Enzymatic reaction;

DOI:10.1248/cpb.57.853

upstream raw materials:

4-bromo-7-hydroxy-5-methoxy-phthalide

2-bromomethyl-6-hydroxy-4-methoxy-benzoic acid ethyl ester

5,7-dimethoxyphthalide

3-benzenesulfinyl-5H-furan-2-one