N-(2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl)-4-methyl benzamide

Base Information

Chemical Name:N-(2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl)-4-methyl benzamide
CAS No.:1044871-62-6
Molecular Formula:C₂₈H₂₉N₃O₅
Molecular Weight:487.555
Hs Code.:

Synonyms:N-(2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl)-4-methyl benzamide

Suppliers and Price of N-(2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl)-4-methyl benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl)-4-methyl benzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl)-4-methyl benzamide

There total 9 articles about N-(2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl)-4-methyl benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1044871-46-6
2-(4-(2-aminoethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one

: 874-60-2
4-methyl-benzoyl chloride

: 1044871-62-6
N-(2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl)-4-methyl benzamide

Guidance literature:: With PS-DIEA; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 21577-57-1
2-amino-4,6-dimethoxybenzoic acid

: 1044871-62-6
N-(2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl)-4-methyl benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / tetrahydrofuran / 3 h / 20 °C

1.2: 16 h / 20 °C

2.1: p-toluenesulfonic acid monohydrate; sodium hydrogensulfite / N,N-dimethyl acetamide / 1.5 h

3.1: tetrahydrofuran / 17 h / 20 °C

4.1: PS-DIEA / dichloromethane / 16 h / 20 °C

With 4-methyl-morpholine; p-toluenesulfonic acid monohydrate; benzotriazol-1-ol; sodium hydrogensulfite; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide;

Reference yield:

: 2233-18-3
4-hydroxy-3,5-dimethylbenzaldehyde

: 1044871-62-6
N-(2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl)-4-methyl benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 2.5 h / 80 °C

2.1: sodium hydrogensulfite; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 1.5 h / Reflux

2.2: 17 h / 20 °C

3.1: PS-DIEA / dichloromethane / 16 h / 20 °C

With potassium carbonate; toluene-4-sulfonic acid; sodium hydrogensulfite; sodium iodide; In dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;