2-(4-(2-aminoethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one

Base Information

• Chemical Name: 2-(4-(2-aminoethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one
• CAS No.: 1044871-46-6
• Molecular Formula: C₂₀H₂₃N₃O₄
• Molecular Weight: 369.42

Synonyms:2-(4-(2-aminoethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one

Chemical Property of 2-(4-(2-aminoethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one

Chemical Property:

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Technology Process of 2-(4-(2-aminoethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one

There total 19 articles about 2-(4-(2-aminoethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

2-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]ethyl}isoindole-1,3-dione (1253732-87-4) + methylamine (74-89-5) → 2-(4-(2-aminoethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one (1044871-46-6)

Guidance literature:

at 20 ℃; for 17h;

Reference yield: 22.0%

2-(2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl)isoindoline-1,3-dione (1044871-91-1) → 2-(4-(2-aminoethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one (1044871-46-6) + 1-N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]ethyl}-2-N-methylphthalic acid diamide (1044871-45-5)

Guidance literature:

With methylamine; In tetrahydrofuran; at 20 ℃; for 17h;

Reference yield: 22.0%

2-(2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl)isoindoline-1,3-dione (1044871-91-1) + methylamine (74-89-5) → 2-(4-(2-aminoethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one (1044871-46-6) + 1-N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]ethyl}-2-N-methylphthalic acid diamide (1044871-45-5)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 17h;

upstream raw materials:

2-(2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl)isoindoline-1,3-dione

methylamine

2-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]ethyl}isoindole-1,3-dione

4,6-dimethoxyindoline-2,3-dione

Downstream raw materials:

N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy]ethyl}-4-methoxybenzene-1-sulfonamide

N-(2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl)-4-methyl benzamide

1-(2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)acetyl)-3-methylurea

N-(2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethyl)propane-2-sulfonamide

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