2-[1-(4-chloro-2-fluoro-benzenesulfonyl)-piperidin-3-yl]-N-piperidin-1-yl-acetamide

Base Information

Chemical Name:2-[1-(4-chloro-2-fluoro-benzenesulfonyl)-piperidin-3-yl]-N-piperidin-1-yl-acetamide
CAS No.:1040879-94-4
Molecular Formula:C₁₈H₂₅ClFN₃O₃S
Molecular Weight:417.932
Hs Code.:

Synonyms:2-[1-(4-chloro-2-fluoro-benzenesulfonyl)-piperidin-3-yl]-N-piperidin-1-yl-acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[1-(4-chloro-2-fluoro-benzenesulfonyl)-piperidin-3-yl]-N-piperidin-1-yl-acetamide

Chemical Property:

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Technology Process of 2-[1-(4-chloro-2-fluoro-benzenesulfonyl)-piperidin-3-yl]-N-piperidin-1-yl-acetamide

There total 8 articles about 2-[1-(4-chloro-2-fluoro-benzenesulfonyl)-piperidin-3-yl]-N-piperidin-1-yl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1040879-99-9
[1-(4-chloro-2-fluoro-benzenesulfonyl)-piperidin-3-yl]-acetic acid

: 2213-43-6
1-Aminopiperidine

: 1040879-94-4
2-[1-(4-chloro-2-fluoro-benzenesulfonyl)-piperidin-3-yl]-N-piperidin-1-yl-acetamide

Guidance literature:: With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 0 - 20 ℃; for 16h;

Reference yield:

: 141337-26-0
4-chloro-2-fluorobenzenesulfonyl chloride

: 1040879-94-4
2-[1-(4-chloro-2-fluoro-benzenesulfonyl)-piperidin-3-yl]-N-piperidin-1-yl-acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 0.33 h / 20 °C

1.2: 0 - 20 °C

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: potassium iodide / N,N-dimethyl-formamide / 80 - 85 °C

4.1: 18-crown-6 ether / N,N-dimethyl-formamide / 16 - 18 h / 20 °C

5.1: hydrogenchloride / 1.5 h

6.1: lithium hydroxide; water / tetrahydrofuran / 16 h / 20 °C

6.2: 0 °C

7.1: dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 16 h / 0 - 20 °C

With hydrogenchloride; dmap; lithium hydroxide; 18-crown-6 ether; water; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; potassium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 4606-65-9
3-(hydroxymethy)piperidine

: 1040879-94-4
2-[1-(4-chloro-2-fluoro-benzenesulfonyl)-piperidin-3-yl]-N-piperidin-1-yl-acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 0.33 h / 20 °C

1.2: 0 - 20 °C

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: potassium iodide / N,N-dimethyl-formamide / 80 - 85 °C

4.1: 18-crown-6 ether / N,N-dimethyl-formamide / 16 - 18 h / 20 °C

5.1: hydrogenchloride / 1.5 h

6.1: lithium hydroxide; water / tetrahydrofuran / 16 h / 20 °C

6.2: 0 °C

7.1: dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 16 h / 0 - 20 °C

With hydrogenchloride; dmap; lithium hydroxide; 18-crown-6 ether; water; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; potassium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;