N-(2,2,2-Trichlor-1-hydroxyethyl)-2,6-difluorbenzolsaeureamid

Base Information

• Chemical Name: N-(2,2,2-Trichlor-1-hydroxyethyl)-2,6-difluorbenzolsaeureamid
• CAS No.: 121583-28-6
• Molecular Formula: C₈H₆Cl₃F₂NO₃S
• Molecular Weight: 340.562
• Mol file: 121583-28-6.mol

Synonyms:N-(2,2,2-Trichlor-1-hydroxyethyl)-2,6-difluorbenzolsaeureamid

Chemical Property of N-(2,2,2-Trichlor-1-hydroxyethyl)-2,6-difluorbenzolsaeureamid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2,2,2-Trichlor-1-hydroxyethyl)-2,6-difluorbenzolsaeureamid

There total 1 articles about N-(2,2,2-Trichlor-1-hydroxyethyl)-2,6-difluorbenzolsaeureamid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

2,6-difluorobenzene-1-sulfonamide (60230-37-7) + chloral (75-87-6) → N-(2,2,2-Trichlor-1-hydroxyethyl)-2,6-difluorbenzolsaeureamid (121583-28-6)

Guidance literature:

With hydrogenchloride; for 16h; Heating;

DOI:10.1007/BF00810285

Reference yield:

N-(2,2,2-Trichlor-1-hydroxyethyl)-2,6-difluorbenzolsaeureamid (121583-28-6) → N-<(4-Methoxypyrimidin-2-ylamino)-2,2,2-trichlorethyl>-2,6-difluorbenzolsulfonsaeureamid (121583-55-9)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / 2 h / Heating

2: Et₃N / toluene / 18 h / Ambient temperature

With thionyl chloride; triethylamine; In toluene;

DOI:10.1007/BF00810285

Reference yield:

N-(2,2,2-Trichlor-1-hydroxyethyl)-2,6-difluorbenzolsaeureamid (121583-28-6) → N-<(4-Methoxy-6-methylpyrimidin-2-ylamino)-2,2,2-trichlorethyl>-2,6-difluorbenzolsulfonsaeureamid (121583-57-1)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / 2 h / Heating

2: Et₃N / toluene / 18 h / Ambient temperature

With thionyl chloride; triethylamine; In toluene;

DOI:10.1007/BF00810285

upstream raw materials:

2,6-difluorobenzene-1-sulfonamide

chloral

Downstream raw materials:

N-<(4-Methoxypyrimidin-2-ylamino)-2,2,2-trichlorethyl>-2,6-difluorbenzolsulfonsaeureamid

N-<(4-Methoxy-6-methylpyrimidin-2-ylamino)-2,2,2-trichlorethyl>-2,6-difluorbenzolsulfonsaeureamid

N-<(4,6-Dimethoxypyrimidin-2-ylamino)-2,2,2-trichlorethyl>-2,6-difluorbenzolsulfonsaeureamid