2-Formyl-naphthalin-benzoylhydrazon

Base Information

• Chemical Name: 2-Formyl-naphthalin-benzoylhydrazon
• CAS No.: 24091-07-4
• Molecular Formula: C₁₈H₁₄N₂O
• Molecular Weight: 274.322
• Mol file: 24091-07-4.mol

Synonyms:2-Formyl-naphthalin-benzoylhydrazon

Chemical Property of 2-Formyl-naphthalin-benzoylhydrazon

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Formyl-naphthalin-benzoylhydrazon

There total 2 articles about 2-Formyl-naphthalin-benzoylhydrazon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzoic acid hydrazide (613-94-5) + β-naphthaldehyde (66-99-9) → (E)-N'-(naphthalen-2-ylmethylene)benzohydrazide (24091-07-4,1338091-78-3)

Guidance literature:

at 20 ℃; for 1h; Neat (no solvent); Ball-milling;

DOI:10.1016/j.tet.2011.07.056

Reference yield: 86.0%

benzoic acid hydrazide (613-94-5) + β-naphthaldehyde (66-99-9) → 2-Formyl-naphthalin-benzoylhydrazon (24091-07-4,1338091-78-3)

Guidance literature:

With acetic acid; In methanol; for 5h; Reflux;

DOI:10.1016/j.jorganchem.2017.08.002

Reference yield: 90.0%

2-Formyl-naphthalin-benzoylhydrazon (24091-07-4,1338091-78-3) + 2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (72824-04-5) → (R)-N'-[1-(naphthalen-2-yl)but-3-enyl]benzohydrazide (1192113-40-8)

Guidance literature:

With indium iodide; 2,2-methylene[(4R,5S)-diphenyl-2-oxazoline]bis[(4R,5S)(diphenyl)-4,5-dihydrooxazol-2-yl]acetonitrile; In methanol; toluene; at 0 ℃; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1002/anie.200906308

upstream raw materials:

benzoic acid hydrazide

β-naphthaldehyde

Downstream raw materials:

(R)-N'-[1-(naphthalen-2-yl)but-3-enyl]benzohydrazide

(1S,2R)-N'-[2-chloro-1-(naphthalen-2-yl)but-3-enyl]benzohydrazide

N-(2,2-difluoro-1-(naphthalen-2-yl)-3-oxo-3-phenylpropyl)benzohydrazide

2-naphthalen-2-yl-5-phenyl-[1,3,4]oxadiazole

Refernces

• 1、 Salum, Lívia B.,Mascarello, Alessandra,Canevarolo, Rafael R.,Altei, Wanessa F.,Laranjeira, Angelo B.A.,Neuenfeldt, Patrícia D.,Stumpf, Taisa R.,Chiaradia-Delatorre, Louise D.,Vollmer, Laura L.,Daghestani, Hikmat N.,De Souza Melo, Carolina P.,Silveira, André B.,Leal, Paulo C.,Frederico, Marisa J.S.,Do Nascimento, Leandro F.,Santos, Adair R.S.,Andricopulo, Adriano D.,Day, Billy W.,Yunes, Rosendo A.,Vogt, Andreas,Yunes, José A.,Nunes, Ricardo J.. "N-(1'-naphthyl)-3,4,5-trimethoxybenzohydrazide as microtubule destabilizer: Synthesis, cytotoxicity, inhibition of cell migration and in vivo activity against acute lymphoblastic leukemia". . p. 504 - 518. Retrieved 2015/05/13.
• 2、 Nun, Pierrick,Martin, Charlotte,Martinez, Jean,Lamaty, Frédéric. "Solvent-free synthesis of hydrazones and their subsequent N-alkylation in a Ball-mill". supporting information; experimental part. p. 8187 - 8194. Retrieved 2011/10/31.