2,2-Difluoro-2-phenylethanaMine HCl

Base Information

• Chemical Name: 2,2-Difluoro-2-phenylethanaMine HCl
• CAS No.: 39625-10-0
• Molecular Formula: C₈H₉F₂N*ClH
• Molecular Weight: 193.624
• Hs Code.: 2921199990
• Mol file: 39625-10-0.mol

Synonyms:2,2-difluoro-2-phenylethanamine hydrochloric acid salt

Chemical Property of 2,2-Difluoro-2-phenylethanaMine HCl

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2,2-Difluoro-2-phenylethanaminehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2,2-Difluoro-2-phenylethanamine Hydrochloride is a central nervous system stimulant in mice.

Technology Process of 2,2-Difluoro-2-phenylethanaMine HCl

There total 2 articles about 2,2-Difluoro-2-phenylethanaMine HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

2,2-difluoro-2-phenylacetamide (383-19-7) → 2,2-difluoro-2-phenylethanamine hydrochloric acid salt (39625-10-0)

Guidance literature:

2,2-difluoro-2-phenylacetamide; With dimethylsulfide borane complex; In tetrahydrofuran; at 0 ℃; for 16h; Reflux;

With hydrogenchloride; In diethyl ether; water; at 20 ℃; for 0.0833333h;

DOI:10.1016/j.bmc.2021.116215

Reference yield:

→ 2,2-difluoro-2-phenylethanamine hydrochloric acid salt (39625-10-0)

Guidance literature:

Reference yield: 86.0%

(3R,4R)-tert-butyl 3-((6-(bis(tert-butoxycarbonyl)amino)-4-methylpyridin-2-yl)methyl)-4-(2-oxoethoxy)pyrrolidine-1-carboxylate (1237495-45-2) + 2,2-difluoro-2-phenylethanamine hydrochloric acid salt (39625-10-0) → (3R,4R)-tert-butyl 3-((6-(bis(tert-butoxycarbonyl)amino)-4-methylpyridin-2-yl)methyl)-4-(2-((2,2-difluoro-2-phenylethyl)amino)ethoxy)pyrrolidine-1-carboxylate

Guidance literature:

With sodium tris(acetoxy)borohydride; triethylamine; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1021/jm200411j

upstream raw materials:

2,2-difluoro-2-phenylacetamide

Downstream raw materials:

2-diazo-acetophenone

methyl 3-benzoylisoxazole-5-carboxylate

[3-(2,2-difluoro-2-phenyl-ethylamino)-2-oxo-2H-pyrazin-1-yl]acetic acid ethyl ester

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