383-19-7

Basic information

• Product Name: 2,2-DIFLUORO-2-PHENYLACETAMIDE
• Synonyms: 2,2-DIFLUORO-2-PHENYLACETAMIDE;2,2-Difluoro-2-phenylacetamide 97%;2,2-Difluoro-2-phenylacetamide97%;2,2-difluoro-2-phenyl-ethanamide
• CAS NO: 383-19-7
• Molecular Formula: C₈H₇F₂NO
• Molecular Weight: 171.14
• Mol File: 383-19-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: 114-115
• Boiling Point: 317°Cat760mmHg
• Flash Point: 145.5°C
• Appearance: /
• Density: 1.269g/cm³
• Vapor Pressure: 0.000395mmHg at 25°C
• Refractive Index: 1.494
• CAS DataBase Reference: 2,2-DIFLUORO-2-PHENYLACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DIFLUORO-2-PHENYLACETAMIDE(383-19-7)
• EPA Substance Registry System: 2,2-DIFLUORO-2-PHENYLACETAMIDE(383-19-7)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 383-19-7(Hazardous Substances Data)

Usage

General Description

2,2-Difluoro-2-phenylacetamide is a chemical compound with the formula C8H7F2NO. It is categorized under the class of organofluorides, mainly involving organic compounds that contain a carbon to fluorine covalent bond. This chemical is often used in the field of synthetic organic chemistry. It involves a fluorine atom, which makes the compound highly reactive and often used as a building block for creating more complex organic materials. It is characterized by its high stability and strong carbon-fluorine bonds. Moreover, the phenyl group present in 2,2-Difluoro-2-phenylacetamide gives the molecule aromatic characteristics, increasing its reactivity as well.

InChI:InChI=1/C8H7F2NO/c9-8(10,7(11)12)6-4-2-1-3-5-6/h1-5H,(H2,11,12)

Upstream product

• 591-50-4 iodobenzene 
• 2169-67-7 2-bromo-2,2-difluoroacetamide 
• 28557-00-8 phenylzinc chloride 
• 40626-45-7 α,α-dichlorobenzylcyanide 
• 1603-79-8 phenylglyoxylic acid ethyl ester 
• 2002-72-4 α,α-difluorobenzeneacetonitrile 

Downstream Products

• 39625-10-0 2,2-difluoro-2-phenylethanamine hydrochloric acid salt 
• 885068-32-6 (6-chloro-2-methoxy-pyrimidin-4-yl)-(2,2-difluoro-2-phenyl-ethyl)-amine 
• 55601-21-3 2,2-difluoro-2-phenylethylamine 
• 650-93-1 2,2-difluoro-2-(3-nitrophenyl)acetic acid 
• 339-30-0 2,2-difluoro-N-2-diphenylacetamide 
• 2248-46-6 ethyl 2,2-difluoro-2-phenylacetate 
• 402-03-9 (3-amino-phenyl)-difluoro-acetic acid 
• 312-24-3 difluoro-phenyl-acetyl chloride 
• 2002-72-4 α,α-difluorobenzeneacetonitrile 
• 360-03-2 2,2-Difluoro-2-phenylacetic acid 

Relevant articles and documents

Direct Approach to 3-Fluoroindoles and 3,3-Difluoroindolines from 2,2-Difluoro-2-phenylethan-1-amines via C-H/N-H Coupling

Herein, a direct method for the synthesis of 3-fluoroindoles and 3,3-difluoroindolines from easily accessible 2,2-difluoro-2-phenyl ethan-1-amines is presented. This protocol was performed by Pd-catalyzed direct C-H/N-H coupling and employed picolinamide as a directing group. By controlling the temperature for this transformation, various 3,3-difluoroindolines and 3-fluoroindoles could be isolated with moderate to good yields.

A COMBINATION OF NIACIN AND A PROSTAGLANDIN D2 RECEPTOR ANTAGONIST

The present invention is directed to a pharmaceutical composition comprising Niacin or a pharmaceutically acceptable salt, solvate or N-oxide thereof, or a nicotinic acid receptor agonist, and a compound of formula (I) as defined herein, or an N-oxide thereof, or an ester prodrug thereof, or a pharmaceutically acceptable salt, hydrate, or solvate thereof, and its use for treating atherosclerosis, dyslipidemia, diabetes or a related condition while reducing substantial flushing.

1,3-DISUBSTITUTED HETEROARYL NMDA/NR2B ANTAGONISTS

Compounds represented by Formula I: (wherein A, B, D, P, Q, R1, R2, R3, W and Y are described herein) or pharmaceutically acceptable salts thereof, are effective as NMDA/NR2B antagonists useful for treating neurological co