ethyl 4-benzyl-6-(2-(1-methyl-1H-pyrazole-4-sulfonamido)ethoxy)chroman-3-ylcarbamate

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Chemical Name:ethyl 4-benzyl-6-(2-(1-methyl-1H-pyrazole-4-sulfonamido)ethoxy)chroman-3-ylcarbamate
CAS No.:1421919-08-5
Molecular Formula:C₂₅H₃₀N₄O₆S
Molecular Weight:514.602
Hs Code.:

Synonyms:ethyl 4-benzyl-6-(2-(1-methyl-1H-pyrazole-4-sulfonamido)ethoxy)chroman-3-ylcarbamate

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Chemical Property of ethyl 4-benzyl-6-(2-(1-methyl-1H-pyrazole-4-sulfonamido)ethoxy)chroman-3-ylcarbamate

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Technology Process of ethyl 4-benzyl-6-(2-(1-methyl-1H-pyrazole-4-sulfonamido)ethoxy)chroman-3-ylcarbamate

There total 9 articles about ethyl 4-benzyl-6-(2-(1-methyl-1H-pyrazole-4-sulfonamido)ethoxy)chroman-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1421919-07-4
2-(4-benzyl-3-(ethoxycarbonylamino)chroman-6-yloxy)ethanaminium chloride

: 288148-34-5
1-methyl-1H-pyrazole-4-sulfonyl chloride

: 1421919-08-5
ethyl 4-benzyl-6-(2-(1-methyl-1H-pyrazole-4-sulfonamido)ethoxy)chroman-3-ylcarbamate

Guidance literature:: With dmap; In dichloromethane; at 20 ℃;

Reference yield:

: 1421919-05-2
ethyl 4-benzyl-6-hydroxychroman-3-ylcarbamate

: 1421919-08-5
ethyl 4-benzyl-6-(2-(1-methyl-1H-pyrazole-4-sulfonamido)ethoxy)chroman-3-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 1 h / 20 °C / Inert atmosphere

1.2: 156.5 h / 20 °C

2.1: hydrogenchloride / dichloromethane; isopropyl alcohol / 20 - 40 °C

3.1: dmap / dichloromethane / 20 °C

With hydrogenchloride; dmap; sodium hydride; In dichloromethane; N,N-dimethyl acetamide; isopropyl alcohol; mineral oil;

Reference yield:

: 1421919-00-7
(Z)-6-methoxychroman-4-one O-tosyl oxime

: 1421919-08-5
ethyl 4-benzyl-6-(2-(1-methyl-1H-pyrazole-4-sulfonamido)ethoxy)chroman-3-ylcarbamate

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium ethanolate / ethanol; toluene / 0 - 20 °C / Inert atmosphere

1.2: 2 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

3.1: tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

4.1: hydrogenchloride / water / 2.5 h / 100 °C

4.2: 0 °C / pH > 10

5.1: palladium on activated charcoal; ammonium formate / water; ethanol / 1.5 h / 70 °C

6.1: boron tribromide / dichloromethane / 2 h / 0 °C / Inert atmosphere

6.2: 0 °C

7.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 1 h / 20 °C / Inert atmosphere

7.2: 156.5 h / 20 °C

8.1: hydrogenchloride / dichloromethane; isopropyl alcohol / 20 - 40 °C

9.1: dmap / dichloromethane / 20 °C

With hydrogenchloride; dmap; palladium on activated charcoal; ammonium formate; sodium ethanolate; boron tribromide; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; water; isopropyl alcohol; toluene; mineral oil;