[4-benzyl-6-(2-tert-butoxycarbonylamino-ethoxy)-chroman-3-yl]-carbamic acid ethyl ester

Base Information

Chemical Name:[4-benzyl-6-(2-tert-butoxycarbonylamino-ethoxy)-chroman-3-yl]-carbamic acid ethyl ester
CAS No.:1421919-06-3
Molecular Formula:C₂₆H₃₄N₂O₆
Molecular Weight:470.566
Hs Code.:

Synonyms:[4-benzyl-6-(2-tert-butoxycarbonylamino-ethoxy)-chroman-3-yl]-carbamic acid ethyl ester

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Chemical Property of [4-benzyl-6-(2-tert-butoxycarbonylamino-ethoxy)-chroman-3-yl]-carbamic acid ethyl ester

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Technology Process of [4-benzyl-6-(2-tert-butoxycarbonylamino-ethoxy)-chroman-3-yl]-carbamic acid ethyl ester

There total 7 articles about [4-benzyl-6-(2-tert-butoxycarbonylamino-ethoxy)-chroman-3-yl]-carbamic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39684-80-5
2-(tert-butoxycarbonylamino)ethyl bromide

: 1421919-05-2
ethyl 4-benzyl-6-hydroxychroman-3-ylcarbamate

: 1421919-06-3
[4-benzyl-6-(2-tert-butoxycarbonylamino-ethoxy)-chroman-3-yl]-carbamic acid ethyl ester

Guidance literature:: ethyl 4-benzyl-6-hydroxychroman-3-ylcarbamate; With sodium hydride; In N,N-dimethyl acetamide; mineral oil; at 20 ℃; for 1h; Inert atmosphere;

2-(tert-butoxycarbonylamino)ethyl bromide; In N,N-dimethyl acetamide; mineral oil; at 20 ℃; for 156.5h;

Reference yield:

: 1421919-00-7
(Z)-6-methoxychroman-4-one O-tosyl oxime

: 1421919-06-3
[4-benzyl-6-(2-tert-butoxycarbonylamino-ethoxy)-chroman-3-yl]-carbamic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium ethanolate / ethanol; toluene / 0 - 20 °C / Inert atmosphere

1.2: 2 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

3.1: tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

4.1: hydrogenchloride / water / 2.5 h / 100 °C

4.2: 0 °C / pH > 10

5.1: palladium on activated charcoal; ammonium formate / water; ethanol / 1.5 h / 70 °C

6.1: boron tribromide / dichloromethane / 2 h / 0 °C / Inert atmosphere

6.2: 0 °C

7.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 1 h / 20 °C / Inert atmosphere

7.2: 156.5 h / 20 °C

With hydrogenchloride; palladium on activated charcoal; ammonium formate; sodium ethanolate; boron tribromide; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; water; toluene; mineral oil;

Reference yield:

: 1421919-01-8
ethyl (6-methoxy-4-oxochroman-3-yl)carbamate

: 1421919-06-3
[4-benzyl-6-(2-tert-butoxycarbonylamino-ethoxy)-chroman-3-yl]-carbamic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2.1: hydrogenchloride / water / 2.5 h / 100 °C

2.2: 0 °C / pH > 10

3.1: palladium on activated charcoal; ammonium formate / water; ethanol / 1.5 h / 70 °C

4.1: boron tribromide / dichloromethane / 2 h / 0 °C / Inert atmosphere

4.2: 0 °C

5.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 1 h / 20 °C / Inert atmosphere

5.2: 156.5 h / 20 °C

With hydrogenchloride; palladium on activated charcoal; ammonium formate; boron tribromide; sodium hydride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; water; mineral oil;