sodium (2S)-2-(6-methoxynaphthalen-2-yl)propanoate

Base Information

• Chemical Name: sodium (2S)-2-(6-methoxynaphthalen-2-yl)propanoate
• CAS No.: 26159-34-2
• Molecular Formula: C14H13O3.Na
• Molecular Weight: 252.245
• Hs Code.: 2918992090
• Mol file: 26159-34-2.mol

Synonyms:sodium (2S)-2-(6-methoxynaphthalen-2-yl)propanoate;SCHEMBL7362;CNQOEXOJUIMDHW-FVGYRXGTSA-N;D79199;(2S)-2-(6-METHOXYNAPHTHALEN-2-YL)PROPANOIC ACID SODIUM;2-Naphthaleneacetic acid, 6-methoxy-a-methyl-, sodium salt, (aS)-

Chemical Property of sodium (2S)-2-(6-methoxynaphthalen-2-yl)propanoate

Chemical Property:

• Appearance/Colour: white powder
• Vapor Pressure: 3.01E-07mmHg at 25°C
• Melting Point: 250-251 °C
• Boiling Point: 403.9 °C at 760 mmHg
• Flash Point: 154.5 °C
• PSA: 49.36000
• Density: ==
• LogP: 1.70180
• Storage Temp.: Desiccate at RT
• Solubility.: Freely soluble in water, freely soluble or soluble in methanol, sparingly soluble in ethanol (96 per cent).
• Water Solubility.: Soluble in water up to 100mg/mlSoluble in methanol and chloroform. Slightly soluble in ether. Insoluble in water.
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 253.08406359
• Heavy Atom Count: 18
• Complexity: 277

Purity/Quality:

99%min ^*data from raw suppliers

(S)-NaproxenSodiumSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn,T
• Statements: 22-61
• Safety Statements: 53-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O.[Na]
• Isomeric SMILES: C[C@@H](C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O.[Na]
• Uses: Used as anti-inflammatory analgesic Naproxen (Aleve, Anaprox) is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively A cyclooxygenase inhibitorNaproxen sodium acts as a nonselective inhibitor of Cox-1 and Cox-2. It serves as an anti-inflammatory agent with analgesic and antipyretic properties. Further, it is used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea and acute gout.

Technology Process of sodium (2S)-2-(6-methoxynaphthalen-2-yl)propanoate

There total 4 articles about sodium (2S)-2-(6-methoxynaphthalen-2-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C14H13O3(1-)*C56H98O35*Na(1+) → heptakis(2,6-di-O-methyl)cyclomaltoheptaose (51166-71-3) + Naprelan (26159-34-2)

Guidance literature:

With pluronic copolymer F₁₂₇; In water; at 25 ℃; Reagent/catalyst; Equilibrium constant;

DOI:10.1021/la100596q

Reference yield:

(2S)-2-(6-methoxy(2-naphthyl))propanoic acid (22204-53-1) → Naprelan (26159-34-2)

Guidance literature:

In methanol;

Reference yield:

racemic 2-(6-methoxy-2-naphthyl)propionic acid + naproxen (23981-80-8) → Naprelan (26159-34-2)

Guidance literature:

With sodium hydroxide; In water; toluene;

upstream raw materials:

naproxen

(2S)-2-(6-methoxy(2-naphthyl))propanoic acid

Downstream raw materials:

(2S)-2-(6-methoxy(2-naphthyl))propanoic acid

6-methoxy-2-acetylnaphthalene

1-(6-methoxy-2-naphthyl)ethanol

Refernces

• 1、 Valero, Margarita,Dreiss, Cecile A.. "Growth, shrinking, and breaking of pluronic micelles in the presence of drugs and/or β-cyclodextrin, a study by small-angle neutron scattering and fluorescence spectroscopy". experimental part. p. 10561 - 10571. Retrieved 2011/01/12.
• 2、 -. "Sodium (S)-2-(6-methoxy-2-naphthyl)propionate monohydrate". . . Retrieved 2008/06/13.