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| CAS No.: | 26159-34-2 |
|---|---|
| Name: | Naproxen sodium |
| Molecular Structure: | |
|
|
|
| Formula: | C14H13O3.Na |
| Molecular Weight: | 252.245 |
| Synonyms: | 2-Naphthaleneaceticacid, 6-methoxy-a-methyl-, sodiumsalt, (S)-;2-Naphthaleneacetic acid, 6-methoxy-a-methyl-, sodium salt, L-(-)- (8CI);(2S)-2-(6-Methoxy-2-naphthyl)propanoic acid sodium salt;Aflaxen;Agilxen;Aleve;Anaprox;Anaprox DS;Apranax;Apraxin;Dafloxen;Duk-F;Flanax;Flanax Forte;Gynestrel;Lefaine;Licorax;Miranax;Naprelan;Naprogesic; |
| EINECS: | 247-486-2 |
| Density: | == |
| Melting Point: | 250-251 °C |
| Boiling Point: | 403.9 °C at 760 mmHg |
| Flash Point: | 154.5 °C |
| Solubility: | Soluble in water up to 100mg/mlSoluble in methanol and chloroform. Slightly soluble in ether. Insoluble in water. |
| Appearance: | white powder |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 22 |
| Safety: | 53-45 |
| PSA: | 49.36000 |
| LogP: | 1.70180 |
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naproxen
- 26159-34-2
Naprelan
| Conditions | Yield |
|---|---|
| With sodium hydroxide In water; toluene |
- 23981-80-8
naproxen
- 26159-34-2
Naprelan
| Conditions | Yield |
|---|---|
| With sodium hydroxide In toluene |
- 22204-53-1
(2S)-2-(6-methoxy(2-naphthyl))propanoic acid
- 26159-34-2
Naprelan
| Conditions | Yield |
|---|---|
| In methanol | |
| With sodium hydroxide In methanol | |
| With sodium hydroxide In methanol at 55℃; Industry scale; | |
| With sodium hydroxide In water Schlenk technique; Inert atmosphere; |
A
- 51166-71-3
heptakis(2,6-di-O-methyl)cyclomaltoheptaose
B
- 26159-34-2
Naprelan
| Conditions | Yield |
|---|---|
| With pluronic copolymer F127 In water at 25℃; Equilibrium constant; Reagent/catalyst; |
- 26159-34-2
Naprelan
- 22204-53-1
(2S)-2-(6-methoxy(2-naphthyl))propanoic acid
| Conditions | Yield |
|---|---|
| With hydrogenchloride In methanol at 20℃; | 98% |
| With hydrogenchloride In water pH=< 2; Inert atmosphere; | 94.3% |
- 52462-29-0
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
- 26159-34-2
Naprelan
| Conditions | Yield |
|---|---|
| In methanol at 20℃; for 1h; Schlenk technique; Inert atmosphere; | 87% |
| In methanol at 20℃; for 4h; | 78% |
- 345911-20-8, 19542-80-4, 158060-65-2, 34795-02-3, 15746-57-3
cis-dichlorobis(2,2′-bipyridine)ruthenium(II)
- 26159-34-2
Naprelan
| Conditions | Yield |
|---|---|
| Stage #1: Naprelan With triethylamine In ethanol at 24.84℃; Stage #2: cis-dichlorobis(2,2′-bipyridine)ruthenium(II) In ethanol for 8h; Reflux; Stage #3: ammonium hexafluorophosphate In ethanol | 66% |
- 26159-34-2
Naprelan
| Conditions | Yield |
|---|---|
| Stage #1: Naprelan With triethylamine In ethanol at 24.84℃; Stage #2: [Ru(1,10-phenanthroline)2Cl2] In ethanol for 8h; Reflux; Stage #3: ammonium hexafluorophosphate In ethanol | 61% |
- 7173-51-5
didecyldimethylammonium chloride
- 26159-34-2
Naprelan
- 934544-44-2
didecyldimethylammonium (S)-6-methoxy-α-methyl-2-naphthaleneacetate
| Conditions | Yield |
|---|---|
| In water at 20℃; for 1h; | 95% |
| Conditions | Yield |
|---|---|
| In water at 20℃; | 86% |
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Specification
The Naproxen sodium, with the CAS registry number 26159-34-2, is also known as 2-Naphthaleneacetic acid,6-methoxy-alpha-methyl-,sodium salt,(S)-. It belongs to the product categories of Essential Chemicals;Reagent Grade;Routine Reagents.Its EINECS number is 247-486-2. This chemical's molecular formula is C14H13NaO3 and molecular weight is 252.24.What's more,Its systematic name is Sodium (-)-2-(6-methoxy-2-naphthyl)propionate.It is an anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout.
Physical properties about Midazolam are:
(1)ACD/LogP: 2.998; (2)# of Rule of 5 Violations: 0; (3)#H bond acceptors: 3; (4)#H bond donors: 1; (5)#Freely Rotating Bonds: 3; (6)Flash Point: 154.5 °C; (7)Enthalpy of Vaporization: 69.1 kJ/mol; (8)Boiling Point: 403.9 °C at 760 mmHg; (9)Vapour Pressure: 3.01E-07 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)SMILES:[Na+].[O-]C(=O)[C@H](c1ccc2c(c1)ccc(OC)c2)C;
(2)Std. InChI:InChI=1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1;
(3)Std. InChIKey:CDBRNDSHEYLDJV-FVGYRXGTSA-M.
The toxicity data of Midazolam as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| child | TDLo | oral | 600mg/kg/30D- (600mg/kg) | KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS | American Journal of Diseases of Children. Vol. 142, Pg. 524, 1988. |