1-(4-methoxybenzyl)-5-methyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester

Base Information

Chemical Name:1-(4-methoxybenzyl)-5-methyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester
CAS No.:942060-21-1
Molecular Formula:C₁₄H₁₇N₃O₃
Molecular Weight:275.307
Hs Code.:

Synonyms:1-(4-methoxybenzyl)-5-methyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester

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Chemical Property of 1-(4-methoxybenzyl)-5-methyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester

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Technology Process of 1-(4-methoxybenzyl)-5-methyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester

There total 4 articles about 1-(4-methoxybenzyl)-5-methyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 141-97-9
ethyl acetoacetate

: 105-13-5
4-Methoxybenzyl alcohol

: 942060-21-1
1-(4-methoxybenzyl)-5-methyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester

Guidance literature:: 4-Methoxybenzyl alcohol; With diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 3.15h; Inert atmosphere;

ethyl acetoacetate; In N,N-dimethyl-formamide; at 60 - 70 ℃; for 36h; regioselective reaction; Inert atmosphere;
DOI:10.1016/j.tetlet.2014.12.019

Reference yield:

: 4341-76-8
Ethyl 2-butynoate

: 70978-37-9
1-(azidomethyl)-4-methoxybenzene

: 942060-21-1
1-(4-methoxybenzyl)-5-methyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester

: 942060-22-2
3-(4-methoxy-benzyl)-5-methyl-3H-[1,2,3]triazole-4-carboxylic acid ethyl ester

Guidance literature:: at 20 - 100 ℃; for 14h;

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 942060-21-1
1-(4-methoxybenzyl)-5-methyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / N,N-dimethyl-formamide / 70 °C

2: potassium carbonate / dimethyl sulfoxide / 48 h / 40 °C

With sodium azide; potassium carbonate; In dimethyl sulfoxide; N,N-dimethyl-formamide;