5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-ethyl-3-(3-oxo-morpholin-4-yl)-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide

Base Information

• Chemical Name: 5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-ethyl-3-(3-oxo-morpholin-4-yl)-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide
• CAS No.: 1184297-35-5
• Molecular Formula: C₂₅H₃₁ClN₄O₇S₂
• Molecular Weight: 599.129
• Mol file: 1184297-35-5.mol

Synonyms:5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-ethyl-3-(3-oxo-morpholin-4-yl)-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide

Chemical Property of 5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-ethyl-3-(3-oxo-morpholin-4-yl)-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-ethyl-3-(3-oxo-morpholin-4-yl)-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide

There total 9 articles about 5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-ethyl-3-(3-oxo-morpholin-4-yl)-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2-ethyl-3-(3-oxomorpholin-4-yl)benzenesulfonyl chloride (1182728-12-6) + 5-chloro-thiophene-2-carboxylic acid [(S)-2-amino-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide (1184297-38-8) → 5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-ethyl-3-(3-oxo-morpholin-4-yl)-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide (1184297-35-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

1,3-dibromobenzene (108-36-1) → 5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-ethyl-3-(3-oxo-morpholin-4-yl)-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide (1184297-35-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / -78 - -65 °C / Inert atmosphere

1.2: 0.33 h / Saturated solution

2.1: n-butyllithium / tetrahydrofuran; n-heptane / 0.25 h / -78 °C

2.2: 0.5 h / -78 °C / Inert atmosphere

2.3: 1.5 h / -78 °C

3.1: potassium carbonate / copper(l) iodide; N,N`-dimethylethylenediamine / toluene / 20 h / 110 °C / Inert atmosphere

4.1: sulfuryl dichloride; water; acetic acid / dichloromethane / 1.58 h / 0 - 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane

With n-butyllithium; sulfuryl dichloride; water; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; copper(l) iodide; N,N`-dimethylethylenediamine; In tetrahydrofuran; n-heptane; dichloromethane; ethylbenzene; toluene;

Reference yield:

1,3-dibromo-2-ethyl-benzene (41053-30-9) → 5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-ethyl-3-(3-oxo-morpholin-4-yl)-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide (1184297-35-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; n-heptane / 0.25 h / -78 °C

1.2: 0.5 h / -78 °C / Inert atmosphere

1.3: 1.5 h / -78 °C

2.1: potassium carbonate / copper(l) iodide; N,N`-dimethylethylenediamine / toluene / 20 h / 110 °C / Inert atmosphere

3.1: sulfuryl dichloride; water; acetic acid / dichloromethane / 1.58 h / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane

With n-butyllithium; sulfuryl dichloride; water; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; copper(l) iodide; N,N`-dimethylethylenediamine; In tetrahydrofuran; n-heptane; dichloromethane; toluene;

upstream raw materials:

2-ethyl-3-(3-oxomorpholin-4-yl)benzenesulfonyl chloride

5-chloro-thiophene-2-carboxylic acid [(S)-2-amino-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide

5-Chlorothiophene-2-carboxylic acid

5-chlorothiophene-2-carbonyl chloride