2-{6-chloro-5-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}butanoic acid methyl ester

Base Information

Chemical Name:2-{6-chloro-5-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}butanoic acid methyl ester
CAS No.:496063-01-5
Molecular Formula:C₂₆H₂₈ClNO₄
Molecular Weight:453.966
Hs Code.:

Synonyms:2-{6-chloro-5-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}butanoic acid methyl ester

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Chemical Property of 2-{6-chloro-5-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}butanoic acid methyl ester

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Technology Process of 2-{6-chloro-5-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}butanoic acid methyl ester

There total 8 articles about 2-{6-chloro-5-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}butanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 496063-00-4
methyl 2-(6-chloro-5-hydroxy-2,3-dihydro-1H-inden-1-yl)butanoate

: 227029-27-8
2-(2-phenyl-5-methyloxazole-4-yl)ethyl methanesulfonate

: 496063-01-5
2-{6-chloro-5-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}butanoic acid methyl ester

Guidance literature:: methyl 2-(6-chloro-5-hydroxy-2,3-dihydro-1H-inden-1-yl)butanoate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃;

2-(2-phenyl-5-methyloxazole-4-yl)ethyl methanesulfonate; In N,N-dimethyl-formamide; mineral oil; at 50 ℃;

Reference yield:

: 1228931-15-4
C₁₃H₁₅NO₄S

: 496063-00-4
methyl 2-(6-chloro-5-hydroxy-2,3-dihydro-1H-inden-1-yl)butanoate

: 496063-01-5
2-{6-chloro-5-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}butanoic acid methyl ester

Guidance literature:: methyl 2-(6-chloro-5-hydroxy-2,3-dihydro-1H-inden-1-yl)butanoate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃;

C₁₃H₁₅NO₄S; In N,N-dimethyl-formamide; mineral oil; at 50 ℃; for 24h;

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; Heating;

Reference yield:

: 98-88-4
benzoyl chloride

: 496063-01-5
2-{6-chloro-5-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl}butanoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / water / 0.5 h / 75 °C

2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 20 °C

2.2: 1 h / -78 - -10 °C

3.1: trichlorophosphate / N,N-dimethyl-formamide / 1 h / 90 °C

4.1: lithium borohydride / tetrahydrofuran / 20 °C

5.1: triethylamine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

6.2: 50 °C

With lithium borohydride; sodium hydride; triethylamine; 1,1'-carbonyldiimidazole; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; water; N,N-dimethyl-formamide; mineral oil;