(S)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-[1,4'-bipiperidin]-2-one hydrochloride

Base Information

Chemical Name:(S)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-[1,4'-bipiperidin]-2-one hydrochloride
CAS No.:1351168-87-0
Molecular Formula:C₁₇H₂₃F₂N₃O₃S*ClH
Molecular Weight:423.912
Hs Code.:

Synonyms:(S)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-[1,4'-bipiperidin]-2-one hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-[1,4'-bipiperidin]-2-one hydrochloride

Chemical Property:

Purity/Quality:

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Technology Process of (S)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-[1,4'-bipiperidin]-2-one hydrochloride

There total 10 articles about (S)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-[1,4'-bipiperidin]-2-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2640-58-6
Nα-benzyloxycarbonyl-L-ornithine

: 1351168-87-0
(S)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-[1,4'-bipiperidin]-2-one hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; tetrahydrofuran / 1 h

1.2: 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0 - 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol

4.1: sodium carbonate / N,N-dimethyl-formamide / 130 °C

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane; methanol / 20 °C

With hydrogenchloride; hydrogen; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1351168-24-5
(S)-tert-butyl 3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-2-oxo-1,4'-bipiperidine-1'-carboxylate

: 1351168-87-0
(S)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-[1,4'-bipiperidin]-2-one hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; dichloromethane; at 20 ℃; Product distribution / selectivity;

Reference yield:

: 851120-61-1
(S)-tert-butyl 3-(benzyloxycarbonylamino)-2-oxo-1,4'-bipiperidin-1'-carboxylate

: 1351168-87-0
(S)-3-(2,5-difluoro-4-(methylsulfonyl)phenylamino)-[1,4'-bipiperidin]-2-one hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / methanol

2: sodium carbonate / N,N-dimethyl-formamide / 130 °C

3: hydrogenchloride / dichloromethane; 1,4-dioxane; methanol / 20 °C

With hydrogenchloride; hydrogen; sodium carbonate; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;