2,4,5-tri-p-methylphenylimidazole

Base Information

• Chemical Name: 2,4,5-tri-p-methylphenylimidazole
• CAS No.: 33515-43-4
• Molecular Formula: C₂₄H₂₂N₂
• Molecular Weight: 338.452
• Mol file: 33515-43-4.mol

Synonyms:2,4,5-tri-p-methylphenylimidazole

Chemical Property of 2,4,5-tri-p-methylphenylimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4,5-tri-p-methylphenylimidazole

There total 13 articles about 2,4,5-tri-p-methylphenylimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

para-methylbenzonitrile (104-85-8) → 2,4,5-tri-p-methylphenylimidazole (33515-43-4)

Guidance literature:

With [(bis(diisopropylphosphino)ethane)Ni(H)]2; hydrogen; at 180 ℃; for 48h; under 6205.94 Torr; neat (no solvent);

DOI:10.1039/c1cc13497c

Reference yield: 95.0%

1,2-di(4-methylphenyl)-1,2-ethanedione (3457-48-5) + 4-methyl-benzaldehyde (104-87-0) → 2,4,5-tri-p-methylphenylimidazole (33515-43-4)

Guidance literature:

With ammonium acetate; at 120 ℃; for 0.0666667h; Microwave irradiation; neat (no solvent);

DOI:10.1080/00397910903043025

Reference yield: 80.0%

4-methyl-benzaldehyde (104-87-0) → 2,4,5-tri-p-methylphenylimidazole (33515-43-4)

Guidance literature:

With iodine; 1,1,1,3,3,3-hexamethyl-disilazane; In acetonitrile; for 4h; Reflux;

DOI:10.5012/bkcs.2012.33.4.1231

upstream raw materials:

2,4,5-tri-p-tolyl-4,5-dihydro-1H-imidazole

1,3,5-tris(4-methylphenyl)-2,4-diazapenta-1,4-diene

dimethyl(phenyl)silyllithium

para-methylbenzonitrile