(S)-methyl 4-<(3,4-dichlorophenyl)acetyl>-3-(hydroxymethyl)-1-piperazinecarboxylate

Base Information

Chemical Name:(S)-methyl 4-<(3,4-dichlorophenyl)acetyl>-3-(hydroxymethyl)-1-piperazinecarboxylate
CAS No.:126766-62-9
Molecular Formula:C₁₅H₁₈Cl₂N₂O₄
Molecular Weight:361.225
Hs Code.:

Synonyms:(S)-methyl 4-<(3,4-dichlorophenyl)acetyl>-3-(hydroxymethyl)-1-piperazinecarboxylate

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Chemical Property of (S)-methyl 4-<(3,4-dichlorophenyl)acetyl>-3-(hydroxymethyl)-1-piperazinecarboxylate

Chemical Property:

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Technology Process of (S)-methyl 4-<(3,4-dichlorophenyl)acetyl>-3-(hydroxymethyl)-1-piperazinecarboxylate

There total 4 articles about (S)-methyl 4-<(3,4-dichlorophenyl)acetyl>-3-(hydroxymethyl)-1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 149715-45-7
(S)-4-(phenylmethyl)-2-piperazinemethanol

: 126766-62-9
(S)-methyl 4-<(3,4-dichlorophenyl)acetyl>-3-(hydroxymethyl)-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 68 percent / H₂, aq. HCl / 10percent Pd/C / tetrahydrofuran / 760 Torr

2: 83 percent / acetonitrile / 0.5 h / Ambient temperature

3: 1.) 1,1'-carbonyldiimidazole, 3.) LiOH

With hydrogenchloride; lithium hydroxide; hydrogen; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm00067a004

Reference yield:

: 149648-95-3
(R)-3-(hydroxymethyl)-1-(phenylmethyl)-2,5-piperazinedione

: 126766-62-9
(S)-methyl 4-<(3,4-dichlorophenyl)acetyl>-3-(hydroxymethyl)-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / Heating

2: 68 percent / H₂, aq. HCl / 10percent Pd/C / tetrahydrofuran / 760 Torr

3: 83 percent / acetonitrile / 0.5 h / Ambient temperature

4: 1.) 1,1'-carbonyldiimidazole, 3.) LiOH

With hydrogenchloride; lithium hydroxide; lithium aluminium tetrahydride; hydrogen; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm00067a004

Reference yield:

: 149648-94-2
N-<(1,1-dimethylethoxy)carbonyl>-N-(phenylmethyl)glycyl-D-serine methyl ester

: 126766-62-9
(S)-methyl 4-<(3,4-dichlorophenyl)acetyl>-3-(hydroxymethyl)-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) SOCl₂, 2.) aq. NH₃ / 1.) methanol, RT, 2 h, 2.) methanol

2: 92 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / Heating

3: 68 percent / H₂, aq. HCl / 10percent Pd/C / tetrahydrofuran / 760 Torr

4: 83 percent / acetonitrile / 0.5 h / Ambient temperature

5: 1.) 1,1'-carbonyldiimidazole, 3.) LiOH

With hydrogenchloride; lithium hydroxide; ammonium hydroxide; lithium aluminium tetrahydride; thionyl chloride; hydrogen; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm00067a004