chiral 4-((3S,3'R,5S,7S,7aR)-6'-chloro-7-(3-chloro-2-fluorophenyl)-5-neopentyl-1,2'-dioxo-3-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-1',2',7,7a-tetrahydrospiro[pyrrolo[1,2-c]imidazole-6,3'-pyrrolo[3,2-c]pyridine]-2(1H,3H,5H)-yl)-3-methoxybenzamide

Base Information

Chemical Name:chiral 4-((3S,3'R,5S,7S,7aR)-6'-chloro-7-(3-chloro-2-fluorophenyl)-5-neopentyl-1,2'-dioxo-3-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-1',2',7,7a-tetrahydrospiro[pyrrolo[1,2-c]imidazole-6,3'-pyrrolo[3,2-c]pyridine]-2(1H,3H,5H)-yl)-3-methoxybenzamide
CAS No.:1396135-14-0
Molecular Formula:C₃₈H₄₂Cl₂FN₅O₅
Molecular Weight:738.686
Hs Code.:

chiral 4-((3S,3'R,5S,7S,7aR)-6'-chloro-7-(3-chloro-2-fluorophenyl)-5-neopentyl-1,2'-dioxo-3-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-1',2',7,7a-tetrahydrospiro[pyrrolo[1,2-c]imidazole-6,3'-pyrrolo[3,2-c]pyridine]-2(1H,3H,5H)-yl)-3-methoxybenzamide

Synonyms:chiral 4-((3S,3'R,5S,7S,7aR)-6'-chloro-7-(3-chloro-2-fluorophenyl)-5-neopentyl-1,2'-dioxo-3-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-1',2',7,7a-tetrahydrospiro[pyrrolo[1,2-c]imidazole-6,3'-pyrrolo[3,2-c]pyridine]-2(1H,3H,5H)-yl)-3-methoxybenzamide

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Chemical Property of chiral 4-((3S,3'R,5S,7S,7aR)-6'-chloro-7-(3-chloro-2-fluorophenyl)-5-neopentyl-1,2'-dioxo-3-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-1',2',7,7a-tetrahydrospiro[pyrrolo[1,2-c]imidazole-6,3'-pyrrolo[3,2-c]pyridine]-2(1H,3H,5H)-yl)-3-methoxybenzamide

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Technology Process of chiral 4-((3S,3'R,5S,7S,7aR)-6'-chloro-7-(3-chloro-2-fluorophenyl)-5-neopentyl-1,2'-dioxo-3-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-1',2',7,7a-tetrahydrospiro[pyrrolo[1,2-c]imidazole-6,3'-pyrrolo[3,2-c]pyridine]-2(1H,3H,5H)-yl)-3-methoxybenzamide

There total 2 articles about chiral 4-((3S,3'R,5S,7S,7aR)-6'-chloro-7-(3-chloro-2-fluorophenyl)-5-neopentyl-1,2'-dioxo-3-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-1',2',7,7a-tetrahydrospiro[pyrrolo[1,2-c]imidazole-6,3'-pyrrolo[3,2-c]pyridine]-2(1H,3H,5H)-yl)-3-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 4-((3S,3'R,5S,7S,7aR)-6'-chloro-7-(3-chloro-2-fluorophenyl)-1'-(1-hydroxy-3-(tetrahydro-2H-pyran-4-yl)propyl)-5-neopentyl-1,2'-dioxo-3-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-1',2',7,7a-tetrahydrospiro[pyrrolo[1,2-c]imidazole-6,3'-pyrrolo[3,2-c]pyridine]-2(1H,3H,5H)-yl)-3-methoxybenzamide

: 1396135-14-0
chiral 4-((3S,3'R,5S,7S,7aR)-6'-chloro-7-(3-chloro-2-fluorophenyl)-5-neopentyl-1,2'-dioxo-3-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-1',2',7,7a-tetrahydrospiro[pyrrolo[1,2-c]imidazole-6,3'-pyrrolo[3,2-c]pyridine]-2(1H,3H,5H)-yl)-3-methoxybenzamide

Guidance literature:: With sodium hydroxide; In ethanol; at 50 ℃; for 1h;

Reference yield:

: 952685-59-5
3-(tetrahydro-2H-pyran-4-yl)propanal

: 1360821-21-1
(2S,3R,4S,5R)-N-(4-carbamoyl-2-methoxyphenyl)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-carboxamide

: 1396135-14-0
chiral 4-((3S,3'R,5S,7S,7aR)-6'-chloro-7-(3-chloro-2-fluorophenyl)-5-neopentyl-1,2'-dioxo-3-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-1',2',7,7a-tetrahydrospiro[pyrrolo[1,2-c]imidazole-6,3'-pyrrolo[3,2-c]pyridine]-2(1H,3H,5H)-yl)-3-methoxybenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / dichloromethane / 1 h / 120 °C / Inert atmosphere; Microwave

2: sodium hydroxide / ethanol / 1 h / 50 °C

With acetic acid; sodium hydroxide; In ethanol; dichloromethane;